Circulating endothelial/skeletal progenitor cells for bone regeneration and healing

被引：140

作者：

Matsumoto, Tomoyuki ^{[1
,2
]}

Kuroda, Ryosuke ^{[1
]}

Mifune, Yutaka ^{[1
,2
]}

Kawamoto, Atsuhiko ^{[2
]}

Shoji, Taro ^{[1
,2
]}

Miwa, Masahiko ^{[1
]}

Asahara, Takayuki ^{[2
,3
]}

Kurosaka, Masahiro ^{[1
]}

机构：

[1] Kobe Univ, Grad Sch Med, Dept Orthopaed Surg, Chuo Ku, Kobe, Hyogo 6500017, Japan

[2] Kobe Inst Biomed Res & Innovat, Kobe, Hyogo, Japan

[3] Tokai Univ, Sch Med, Dept Regenerat Med Sci, Tokai, Ibaraki, Japan

来源：

BONE | 2008年 / 43卷 / 03期

关键词：

circulating skeletal progenitor cells; endothelial progenitor cells; bone regeneration; vasculogenesis CD34+cells;

D O I：

10.1016/j.bone.2008.05.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An emerging strategy in the regeneration and repair of bone is to use stem cells, including bone marrow mesenchymal stem cells, which are the most investigated and reliable source for tissue engineering, as well as circulating skeletal stem/progenitor cells, which are receiving abundant attention in regenerative medicine due to their ease of isolation and high osteogenic potential. Because failures in fracture healing are largely due to poor vascularization among many environmental factors, we highlight the first proof-of-principle experiments that elucidated the collaborative multi-lineage differentiation Of circulating CD34 positive cells - a cell-enriched population of endothelial/hematopoietic progenitor cells - into not only endothelial cells but also osteoblasts. These cells develop a favorable environment for fracture healing via vasculogenesis/angiogenesis and osteogenesis, ultimately leading to functional recovery from fracture. This review will also highlight current concepts of circulating stem/progenitor cell-based therapy and their potential application for bone repair. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：434 / 439

页数：6

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