International Reporting Scale of BCR-ABL1 Fusion Transcript in Chronic Myeloid Leukemia: First Report from India

被引：6

作者：

Balasubramanian, Poonkuzhali ^{[1
]}

Chendamarai, Ezhilarasi ^{[1
]}

Markose, Preetha ^{[1
]}

Fletcher, Linda ^{[2
,3
]}

Branford, Susan ^{[2
,3
]}

George, Biju ^{[1
]}

Mathews, Vikram ^{[1
]}

Chandy, Mammen ^{[1
]}

Srivastava, Alok ^{[1
]}

机构：

[1] Christian Med Coll & Hosp, Dept Haematol, Vellore 632004, Tamil Nadu, India

[2] SA Pathol, Adelaide, SA, Australia

[3] Univ Adelaide, Adelaide, SA, Australia

来源：

ACTA HAEMATOLOGICA | 2012年 / 127卷 / 03期

关键词：

BCR-ABL1; transcripts; Chronic myeloid leukemia; Complete cytogenetic response; Major molecular response; MINIMAL-RESIDUAL-DISEASE; GENE TRANSCRIPTS; RECOMMENDATIONS; INTERFERON; IMATINIB; THERAPY; PCR;

D O I：

10.1159/000334716

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Achieving a major molecular response (MMR) is an important predictor of progression-free survival in chronic myeloid leukemia patients treated with imatinib. This requires accurate measurement of BCR-ABL1 transcripts normalized to a control gene, as well as defining a level (BCR-ABL1/control gene ratio) that will correlate with sustained clinical response. To make these measurements comparable between laboratories, an international scale (IS) is necessary. A BCR-ABL1/control gene ratio of 0.10% represents MMR in the IS. In collaboration with an international reference laboratory in Adelaide, S.A., Australia, we have established and validated a lab-specific conversion factor for expressing BCR-ABL1 transcript levels in the IS. In this report, we explain the process and steps involved in obtaining a valid lab-specific conversion factor for expressing BCR-ABL1 transcript levels in the IS. Copyright (C) 2012 S. Karger AG, Basel

引用

页码：135 / 142

页数：8

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