Fe(III)-mediated isomerization of α, α-diarylallylic alcohols to ketones via radical 1,2-aryl migration

被引：24
|
作者：
Deng, Ziyang [1 ]
Chen, Changwei [1 ]
Cui, Sunliang [1 ]
机构：
[1] Zhejiang Univ, Inst Drug Discovery & Dev, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China
来源：
RSC ADVANCES | 2016年 / 6卷 / 96期
关键词：
ALPHA; ALPHA-DIARYL ALLYLIC ALCOHOLS; UNACTIVATED ALKENES; CATALYZED TRIFLUOROMETHYLATION; FUNCTIONALIZED KETONES; OLEFIN HYDROAMINATION; FE;
D O I：
10.1039/c6ra20007a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An Fe(III)-mediated radical 1,2-aryl migration of alpha, alpha-diarylallylic alcohols for the isomerization to ketones is described. The Fe(acac)(3)-silane would convert the alkene to an alkyl radical and initiates a 1,2-aryl migration-oxidation process. Thus Fe(acac)(3) serves as an olefin hydrogen atom transfer initiator and oxidant, while various allylic alcohols could isomerize to ketones in moderate to good yields.
引用
收藏
页码：93753 / 93755
页数：3
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