Up-regulation of Fas ligand and down-regulation of Fas expression in oral carcinogenesis

被引:33
作者
Chen, QM [1 ]
Samaranayake, LP
Zhen, X
Luo, G
Nie, MH
Li, BQ
机构
[1] Univ Hong Kong, Oral Biosci Labs, Fac Dent, Hong Kong, Peoples R China
[2] W China Univ Med Sci, Coll Stomatol, Chengdu, Peoples R China
关键词
Fas; FasL; oral; premalignant lesions; squamous cell carcinoma;
D O I
10.1016/S1368-8375(99)00029-9
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
An important molecule involved in delivering the death signal that initiates apoptosis is called Fas, or Apo-1, which sits on the cell surface. When another molecule called the Fas ligand (FasL) binds to it, Fas triggers a series of events inside the cell that leads to apoptosis. In order to investigate the mechanism of immune escape and the expression of Pas and Fast in oral premalignant lesions (OPLs) and oral squamous cell carcinomas (OSCCs), a total of 64 samples were evaluated by an immunohistochemical method using a labelled streptavidin-biotin assay. These samples comprised nine hyperkeratotic and 24 oral premalignant lesions (nine of mild, moderate, and six of severe dysplastic lesions), and 24 OSCCs, together with seven healthy controls. The results demonstrated that the majority of invasive OSCCs showed down-regulation of Fas expression but up-regulation of Fast expression. These phenomena were also detected in OPLs. The results indicate that the expression of Fas and FasL is involved in oral carcinogenesis and this may be a mechanism by which the cancer cells evade the host immune assault. Perhaps, in future, Fas/FasL system may be used as a prognostic biomarker in predicting the behavior of oral premalignant lesions. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:548 / 553
页数:6
相关论文
共 25 条
  • [1] Oral white lesions with special reference to precancerous and tobacco related lesions: Conclusions of an international symposium held in Uppsala, Sweden, May 18-21 1994
    Axell, T
    Pindborg, JJ
    Smith, CJ
    vanderWaal, I
    [J]. JOURNAL OF ORAL PATHOLOGY & MEDICINE, 1996, 25 (02) : 49 - 54
  • [2] Chen QM, 1999, J ORAL PATHOL MED, V28, P158
  • [3] Apoptosis in oral erythema multiforme
    Chrysomali, E
    LozadaNur, F
    Dekker, NP
    Papanicolaou, SI
    Regezi, JA
    [J]. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 1997, 83 (02): : 272 - 280
  • [4] Apoptosis-associated markers in oral lichen planus
    Dekker, NP
    LozadaNur, F
    Lagenaur, LA
    MacPhail, LA
    Bloom, CY
    Regezi, JA
    [J]. JOURNAL OF ORAL PATHOLOGY & MEDICINE, 1997, 26 (04) : 170 - 175
  • [5] FRECH LE, 1996, J CELL BIOL, V133, P335
  • [6] Gratas C, 1998, CANCER RES, V58, P2057
  • [7] Fas ligand expression in glioblastoma cell lines and primary astrocytic brain tumors
    Gratas, C
    Tohma, Y
    Van Meir, EG
    Klein, M
    Tenan, M
    Ishii, N
    Tachibana, O
    Kleihues, P
    Ohgaki, H
    [J]. BRAIN PATHOLOGY, 1997, 7 (03) : 863 - 869
  • [8] Melanoma cell expression of Fas(Apo-1/CD95) ligand: Implications for tumor immune escape
    Hahne, M
    Rimoldi, D
    Schroter, M
    Romero, P
    Schreier, M
    French, LE
    Schneider, P
    Bornand, T
    Fontana, A
    Lienard, D
    Cerottini, JC
    Tschopp, J
    [J]. SCIENCE, 1996, 274 (5291) : 1363 - 1366
  • [9] Activated B cells express functional Fas ligand
    Hahne, M
    Renno, T
    Schroeter, M
    Irmler, M
    French, L
    Bornand, T
    MacDonald, HR
    Tschopp, J
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (03) : 721 - 724
  • [10] LEITHAUSER F, 1993, LAB INVEST, V69, P415