Fabrication and characterization of bioactive calcium silicate microspheres for drug delivery

被引：29

作者：

Lin, Kaili ^{[1
]}

Zhai, Dong ^{[1
]}

Zhang, Na ^{[1
]}

Kawazoe, Naoki ^{[2
]}

Chen, Guoping ^{[2
]}

Chang, Jiang ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

[2] Natl Inst Mat Sci, Int Ctr Mat Nanoarchitecton, Tissue Regenerat Mat Unit, Tsukuba, Ibaraki 3050044, Japan

来源：

CERAMICS INTERNATIONAL | 2014年 / 40卷 / 02期

关键词：

Calcium silicate; Microspheres; Bioactivity; Cell proliferation; Drug delivery; HYDROXYAPATITE POROUS MICROSPHERES; FREE HYDROTHERMAL SYNTHESIS; SUBSTITUTED HYDROXYAPATITE; IN-VITRO; RELEASE; BIOCERAMICS; CERAMICS; TISSUE; BIOCOMPATIBILITY; DIFFERENTIATION;

D O I：

10.1016/j.ceramint.2013.09.106

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The calcium silicate (CaSiO3, CS) microspheres with diameter of 75-100 mu m were fabricated by a spray-drying method. A new bone-like apatite layer fully covered the surface of the fabricated CS microspheres after soaking in simulated body fluid (SBF), suggesting the excellent activity of the material in inducing apatite deposition. The ionic extracts of CS microspheres promoted the proliferation of human osteoblast-like cells (MC3T3-E1). In addition, the porous structures of the CS microspheres resulted in favorable drug loading and sustained release property. Our study indicates that the fabricated multifunctional CS microspheres are a promising drug delivery system as an injectable bioactive filling material for bone-regeneration. (C) 2013 Elsevier Ltd and Techna Group S.r.l. All rights reserved.

引用

页码：3287 / 3293

页数：7

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