SWI/SNF (BAF) Complexes: Guardians of the Epigenome

被引：30
作者：
Mathur, Radhika [1 ,2 ]
Roberts, Charles W. M. [3 ,4 ]
机构：
[1] Harvard Med Sch, Program Biol & Biomed Sci, Boston, MA 02215 USA
[2] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02215 USA
[3] St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USA
[4] St Jude Childrens Res Hosp, Ctr Comprehens Canc, Memphis, TN 38105 USA
来源：
ANNUAL REVIEW OF CANCER BIOLOGY, VOL 2 | 2018年 / 2卷
基金：
美国国家卫生研究院;
关键词：
SWI/SNF complexes; chromatin; transcriptional regulation; enhancers; CHROMATIN-REMODELING COMPLEX; MALIGNANT RHABDOID TUMORS; SUPPRESSOR SNF5 LEADS; SMALL-CELL CARCINOMA; TRANSCRIPTIONAL ENHANCERS; SMARCA4; MUTATIONS; GENETIC-ANALYSIS; PROSTATE-CANCER; TARGETING EZH2; GERM-LINE;
D O I：
10.1146/annurev-cancerbio-030617-050151
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The genomics-era search for cancer-causing mutations has identified subunits of SWI/SNF (BAF) chromatin remodeling complexes as major targets of mutation. The mechanism by which mutations in SWI/SNF complexes might drive cancer has become the subject of debate, as these complexes have roles in both transcriptional regulation and maintenance of genomic integrity. Recent discoveries now reveal that SWI/SNF complexes broadly control the activity of transcriptional enhancers to regulate lineage-specific differentiation. Here, we synthesize an integrative model of SWI/SNF complex function, identifying perturbed control of enhancer activity as the central mechanism underlying tumor suppression and highlighting how this yields new opportunities for therapeutic intervention.
引用
收藏
页码：413 / 427
页数：15
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