Effects of Simvastatin on bone healing around titanium implants in osteoporotic rats

被引:94
作者
Du, Zhibin [1 ]
Chen, Jiang [1 ]
Yan, Fuhua [1 ]
Xiao, Yin [2 ]
机构
[1] Fujian Med Univ, Affiliated Stomatol Hosp, Dept Oral Implant, Fuzhou, Peoples R China
[2] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4001, Australia
关键词
osseointegration; osteoporosis; Simvastatin; titanium implants; HYDROXYAPATITE-COATED IMPLANTS; MINERAL DENSITY; OVARIECTOMIZED RATS; STATINS; FRACTURE; METAANALYSIS; TURNOVER; CELLS; WOMEN; RISK;
D O I
10.1111/j.1600-0501.2008.01630.x
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Osteoporosis is known to impair the process of implant osseointegration. The recent discovery that statins (HMG-CoA reductase inhibitors) act as bone anabolic agents suggests that statins can be used as potential agents in the treatment of osteoporosis. Therefore, we hypothesized that statins will promote osteogenesis around titanium implants in subjects with osteoporosis. Fifty-four female Sprague Dawley rats, aged 3 months old, were randomly divided into three groups: Sham-operated group (SHAM; n=18), ovariectomized group (OVX; n=18), and ovariectomized with Simvastatin treatment group (OVX+SIM; n=18). Fifty-six days after being ovariectomized (OVX), screw-shaped titanium implants were inserted into the tibiae. Simvastatin was administered orally at 5 mg/kg each day after the placement of the implant in the OVX+SIM group. The animals were sacrificed at either 28 or 84 days after implantation and the undecalcified tissue sections were obtained. Bone-to-implant contact (BIC) and bone area (BA) within the limits of implant threads were measured around the cortical (zone A) and cancellous (zone B) bone regions. Furthermore, bone density (BD) of zone B in a 500 mu m wide zone lateral to the implants was also measured. There were no significant differences in BIC and BA measurements in zone A in any of the three groups at either 28 or 84 days after implantation (P > 0.05). By contrast, in zone B, significant differences in the measurement of BIC, BA, and BD were observed at 28 and 84 days between all three groups. Bone healing decreased with lower BIC, BA, and BD around implant in OVX group compared with other two groups, and Simvastatin reversed the negative effect of OVX on bone healing around implants with the improvement of BIC, BA, and BD in zone B. Osteoporosis can significantly influence bone healing in the cancellous bone around titanium implants and Simvastatin was shown to significantly improve the osseointegration of pure titanium implants in osteoporotic rats. To cite this article:Du Z, Chen J, Yan F, Xiao Y. The effects of Simvastatin on bone healing around titanium implants in osteoporotic rats.Clin. Oral Impl. Res. 20, 2009; 145-150.doi: 10.1111/j.1600-0501.2008.01630.x.
引用
收藏
页码:145 / 150
页数:6
相关论文
共 25 条
[1]   Simvastatin promotes osteogenesis around titanium implants - A histological and histometrical study in rats [J].
Ayukawa, Y ;
Okamura, A ;
Koyano, K .
CLINICAL ORAL IMPLANTS RESEARCH, 2004, 15 (03) :346-350
[2]   Use of statins and fracture - Results of 4 prospective studies and cumulative meta-analysis of observational studies and controlled trials [J].
Bauer, DC ;
Mundy, GR ;
Jamal, SA ;
Black, DM ;
Cauley, JA ;
Ensrud, KE ;
van der Klift, M ;
Pols, HAP .
ARCHIVES OF INTERNAL MEDICINE, 2004, 164 (02) :146-152
[3]   Age-related and surgically induced estrogen deficiencies may differently affect bone around titanium implants in rats [J].
Duarte, PM ;
Gonçalves, PF ;
Casati, MZ ;
Sallum, EA ;
Nociti, FH .
JOURNAL OF PERIODONTOLOGY, 2005, 76 (09) :1496-1501
[4]  
Duarte Poliana Mendes, 2003, Implant Dent, V12, P340
[5]   Estradiol increases glucagon's satiating potency in ovariectomized rats [J].
Geary, N ;
Asarian, L .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2001, 281 (04) :R1290-R1294
[6]   New addition to the statin's effect [J].
Kiliccoglu, Sibel Serin ;
Erdemli, Esra .
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 2007, 63 (01) :187-191
[7]  
Lugero G G, 2000, Implant Dent, V9, P303, DOI 10.1097/00008505-200009040-00005
[8]   Statins augment vascular endothelial growth factor expression in osteoblastic cells vial inhibition of protein prenylation [J].
Maeda, T ;
Kawane, T ;
Horiuchi, N .
ENDOCRINOLOGY, 2003, 144 (02) :681-692
[9]   Induction of osteoblast differentiation indices by statins in MC3T3-E1 cells [J].
Maeda, T ;
Matsunuma, A ;
Kurahashi, I ;
Yanagawa, T ;
Yoshida, H ;
Horiuchi, N .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2004, 92 (03) :458-471
[10]   Effect of simvastatin treatment on bone mineral density and bone turnover in hypercholesterolemic postmenopausal women: a 1-year longitudinal study [J].
Montagnani, A ;
Gonnelli, S ;
Cepollaro, C ;
Pacini, S ;
Campagna, MS ;
Franci, MB ;
Lucani, B ;
Gennari, C .
BONE, 2003, 32 (04) :427-433