Oxal hydroxamic acid derivatives with inhibitory activity against matrix metalloproteinases

被引：10

作者：

Krumme, D ^{[1
]}

Tschesche, H ^{[1
]}

机构：

[1] Univ Bielefeld, Dept Biochem 1, D-33615 Bielefeld, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(02)00052-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several amines, amino acid derivatives and low molecular weight peptides containing an amide-bound oxal hydroxamic acid moiety have been synthesized and tested for their inhibitory effects towards native human gelatinase B (MMP-9) and the catalytic domains of the membrane type MT1-MMP (MMP-14) and of neutrophil collagenase (MMP-8). A number of these compounds exhibited considerable inhibitory activity against the tested metalloproteinases. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：933 / 936

页数：4

共 9 条

[1] Matrix metalloproteinase inhibitors 1998 [J].

Beckett, RP ;

Whittaker, M .

EXPERT OPINION ON THERAPEUTIC PATENTS, 1998, 8 (03) :259-282

[2] MATRIX METALLOPROTEINASES - A REVIEW [J].

BIRKEDALHANSEN, H ;

MOORE, WGI ;

BODDEN, MK ;

WINDSOR, LJ ;

BIRKEDALHANSEN, B ;

DECARLO, A ;

ENGLER, JA .

CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE, 1993, 4 (02) :197-250

[3] Matrix metalloproteases: variations on a theme [J].

Borkakoti, N .

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1998, 70 (01) :73-94

[4] Matrix metalloproteinases: molecular aspects of their roles in tumour invasion and metastasis [J].

Curran, S ;

Murray, GI .

EUROPEAN JOURNAL OF CANCER, 2000, 36 (13) :1621-1630

[5] Hydroxamate derivatives of substrate-analogous peptides containing aminomalonic acid are potent inhibitors of matrix metalloproteinases [J].

Krumme, D ;

Wenzel, H ;

Tschesche, H .

FEBS LETTERS, 1998, 436 (02) :209-212

[6]

KRUMME D, 2000, THESIS U BIELEFELD

[7] Matrix metalloproteinases: multifunctional contributors to tumor progression [J].

McCawley, LJ ;

Matrisian, LM .

MOLECULAR MEDICINE TODAY, 2000, 6 (04) :149-156

[8]

Montana J, 2000, Curr Opin Drug Discov Devel, V3, P353

[9] Matrix metalloproteinase inhibitors: Applications in oncology [J].

Yip, D ;

Ahmad, A ;

Karapetis, CS ;

Hawkins, CA ;

Harper, PG .

INVESTIGATIONAL NEW DRUGS, 1999, 17 (04) :387-399

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