Recent progress of in situ formed gels for biomedical applications

被引：348

作者：

Ko, Du Young ^{[1
]}

Shinde, Usha Pramod ^{[1
]}

Yeon, Bora ^{[2
]}

Jeong, Byeongmoon ^{[1
,2
]}

机构：

[1] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea

[2] Ewha Womans Univ, Dept Bioinspired Sci WCU, Seoul 120750, South Korea

来源：

PROGRESS IN POLYMER SCIENCE | 2013年 / 38卷 / 3-4期

基金：

新加坡国家研究基金会;

关键词：

In situ hydrogel; Biomedical technology; Physicochemical association; Biodegradable; Water soluble monomers; MESENCHYMAL STEM-CELLS; HYALURONIC-ACID HYDROGELS; BLOCK-COPOLYMER HYDROGELS; REVERSE THERMAL GELATION; INJECTABLE THERMOSENSITIVE HYDROGEL; OXIDE) TRIBLOCK COPOLYMERS; CROSS-LINKED CHITOSAN; POLY(ETHYLENE GLYCOL); BIODEGRADABLE HYDROGELS; PHOTOCROSSLINKABLE HYALURONAN;

D O I：

10.1016/j.progpolymsci.2012.08.002

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

With the rapid progress of biomedical technology, hydrogels that can be prepared under bio-friendly conditions are urgently needed. In situ gelling systems have been extensively investigated with the aim of being applied for minimally invasive drug delivery or injectable tissue engineering. In a premixed state of an aqueous solution, the system contains drugs or cells and other excipients. Chemical or physical triggering processes produce a hydrogel in situ. During the solution-to-gel transition process, all of the ingredients in the system form a matrix, where the drugs can be slowly released or within which cells/stem cells can grow in a specifically controlled manner. Basically, the triggering process and transition should not damage the incorporated elements, including pharmaceuticals, and cells, including stem cells. In addition, once it is formed, a hydrogel should provide a compatible microenvironment for the drugs and cells. Finally the hydrogel should be eliminated from the site after its role as a scaffold or depot is complete. In this review, in situ gelling systems were classified into chemical reaction driven gelation and physicochemical association driven gelation. The triggering mechanism involved in each process and the characteristics of each system are comparatively discussed. In addition, our perspectives on the in situ gelling systems are offered as signposts for the future advancement of this field. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：672 / 701

页数：30

共 250 条

[21] Incorporation of tissue-specific molecules alters chondrocyte metabolism and gene expression in photocrosslinked hydrogels [J].

Bryant, SJ ;

Arthur, JA ;

Anseth, KS .

ACTA BIOMATERIALIA, 2005, 1 (02) :243-252

[22] Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks [J].

Burdick, JA ;

Chung, C ;

Jia, XQ ;

Randolph, MA ;

Langer, R .

BIOMACROMOLECULES, 2005, 6 (01) :386-391

[23] Hyaluronic Acid Hydrogels for Biomedical Applications [J].

Burdick, Jason A. ;

Prestwich, Glenn D. .

ADVANCED MATERIALS, 2011, 23 (12) :H41-H56

[24] A novel enzymatic technique for limiting drug mobility in a hydrogel matrix [J].

Burke, MD ;

Park, JO ;

Srinivasarao, M ;

Khan, SA .

JOURNAL OF CONTROLLED RELEASE, 2005, 104 (01) :141-153

[25] Oxidation of recombinant human interleukin-2 by potassium peroxodisulfate [J].

Cadée, JA ;

van Steenbergen, MJ ;

Versluis, C ;

Heck, AJR ;

Underberg, WJM ;

den Otter, W ;

Jiskoot, W ;

Hennink, WE .

PHARMACEUTICAL RESEARCH, 2001, 18 (10) :1461-1467

[26] Injectable glycosaminoglycan hydrogels for controlled release of human basic fibroblast growth factor [J].

Cai, SS ;

Liu, YC ;

Shu, XZ ;

Prestwich, GD .

BIOMATERIALS, 2005, 26 (30) :6054-6067

[27] A new process for cell microencapsulation and other biomaterial applications: Thermal gelation and chemical cross-linking in 'tandem' [J].

Cellesi, F ;

Tirelli, N .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2005, 16 (06) :559-565

[28] Towards a fully-synthetic substitute of alginate: development of a new process using thermal gelation and chemical cross-linking [J].

Cellesi, F ;

Tirelli, N ;

Hubbell, JA .

BIOMATERIALS, 2004, 25 (21) :5115-5124

[29]

Cellesi F, 2002, MACROMOL CHEM PHYSIC, V203, P1466, DOI 10.1002/1521-3935(200207)203:10/11<1466::AID-MACP1466>3.0.CO

[30]

2-P

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