Chemical and etiological studies on tetrodotoxin and its analogs

被引：79
作者：
Yasumoto, T
YotsuYamashita, M
机构：
[1] Faculty of Agriculture, Tohoku University, Aoba-ku, Sendai 981
来源：
JOURNAL OF TOXICOLOGY-TOXIN REVIEWS | 1996年 / 15卷 / 02期
关键词：
D O I：
10.3109/15569549609064078
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
The marked fluctuation of tetrodotoxin (TTX) contents in pufferfish led us to suspect the exogenous origin of the toxin. Based on a food chain hypothesis, various marine biota were tested for TTX with a fluorometric tetrodotoxin analyzer. Consequently, bacteria were found to be the genetic origin of TT. The survey also revealed the occurrence of new TTX analogs in pufferfish, newts and a frog. Those analogs were isolated and their chemical structures were determined. The analogs provided valuable information on biosynthetic as well as metabolic pathways of TTX and on structure-activity relationship.
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页码：81 / 90
页数：10
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