Targeting SCF E3 Ligases for Cancer Therapies

被引：34

作者：

Liu, Jing ^{[1
,2
]}

Peng, Yunhua ^{[1
,2
,3
]}

Zhang, Jinfang ^{[3
]}

Long, Jiangang ^{[1
,2
]}

Liu, Jiankang ^{[1
,2
]}

Wei, Wenyi ^{[3
]}

机构：

[1] Xi An Jiao Tong Univ, Key Lab Biomed Informat Engn, Ctr Mitochondrial Biol & Med, Minist Educ,Sch Life Sci & Technol, Xian, Peoples R China

[2] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian, Peoples R China

[3] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02115 USA

来源：

CULLIN-RING LIGASES AND PROTEIN NEDDYLATION: BIOLOGY AND THERAPEUTICS | 2020年 / 1217卷

关键词：

SCF E3 ligase; SKP2; FBW7; beta-TRCP; Cancer; F-BOX PROTEIN; I-KAPPA-B; KINASE-ASSOCIATED PROTEIN-2; SMALL-MOLECULE INHIBITORS; PHOSPHORYLATION-DEPENDENT UBIQUITINATION; MAMMARY-GLAND DEVELOPMENT; HUMAN PROSTATE-CANCER; STEM-CELL QUIESCENCE; CYCLIN-E DEGRADATION; BETA-TRCP;

D O I：

10.1007/978-981-15-1025-0_9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SKP1-cullin-1-F-box-protein (SCF) E3 ubiquitin ligase complex is responsible for the degradation of proteins in a strictly regulated manner, through which it exerts pivotal roles in regulating various key cellular processes including cell cycle and division, apoptosis, and differentiation. The substrate specificity of the SCF complex largely depends on the distinct F-box proteins, which function in either tumor promotion or suppression or in a context-dependent manner. Among the 69 F-box proteins identified in human genome, FBW7, SKP2, and beta-TRCP have been extensively investigated among various types of cancer in respective of their roles in cancer development, progression, and metastasis. Moreover, several specific inhibitors have been developed to target those E3 ligases, and their efficiency in tumors has been determined. In this review, we provide a summary of the roles of SCF E3 ligases in cancer development, as well as the potential application of miRNA or specific inhibitors for cancer therapy.

引用

页码：123 / 146

页数：24

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