Cytotoxic and Urease Inhibition Potential of Moringa peregrina Seed Ethanolic Extract

Background and Objective: Moringa peregrina have long been used as traditional medicine to treat diseases including fever, ulcer, burns and constipation, antimicrobial and inflammatory throughout the African mainland. The objectives of current study were to evaluate the cytotoxic and urease inhibitory profile of Moringa peregrina seed ethanolic extract (MPSE). Materials and Methods: Brine shrimp lethality bioassay was used to determine the cytotoxic effect of MPSE treatment at concentrations 1000, 100 and 10 mu g mL(-1). Urease inhibition was determined by in vitro Indophenol inhibition assays. Results: It is found that the Moringa peregrina seed ethanolic extract was not cytotoxic at 1000 mu g mL(-1) while significantly active with urease inhibitor (81.30 +/- 0.31% at 0.2 mg mL(-1)) with IC50 values of 41.0 +/- 0.6 mu g mL(-1). Conclusion: These findings suggested that the Moringa peregrina seed ethanol extract (MPSE) can be utilized to treat and prevent ulcerative and Urolithiasis diseases through urease inhibition process. Seed extract of M. peregrina is a remarkable candidate for further clinical investigation studies to screen out their natural therapeutic potential in ulcerative and urolithiasis diseases.