Measuring three-dimensional interaction potentials using optical interference

被引：20
作者：
Mojarad, Nassir [1 ]
Sandoghdar, Vahid [2 ]
Krishnan, Madhavi [3 ,4 ]
机构：
[1] Paul Scherrer Inst, Lab Micro & Nanotechnol, CH-5232 Villigen, Switzerland
[2] Max Planck Inst Sci Light, D-91058 Erlangen, Germany
[3] Univ Zurich, Inst Phys Chem, CH-8057 Zurich, Switzerland
[4] Univ Zurich, Inst Phys, CH-8057 Zurich, Switzerland
来源：
OPTICS EXPRESS | 2013年 / 21卷 / 08期
基金：
瑞士国家科学基金会;
关键词：
PARTICLE TRACKING; MICROSCOPY; NANOPARTICLES; FORCES; SPECTROSCOPY; DIFFRACTION; SURFACES; POSITION; OBJECTS; RANGE;
D O I：
10.1364/OE.21.009377
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
We describe the application of three-dimensional (3D) scattering interferometric (iSCAT) imaging to the measurement of spatial interaction potentials for nano-objects in solution. We study electrostatically trapped gold particles in a nanofluidic device and present details on axial particle localization in the presence of a strongly reflecting interface. Our results demonstrate high-speed (similar to kHz) particle tracking with subnanometer localization precision in the axial and average 2.5 nm in the lateral dimension. A comparison of the measured levitation heights of trapped particles with the calculated values for traps of various geometries reveals good agreement. Our work demonstrates that iSCAT imaging delivers label-free, high-speed and accurate 3D tracking of nano-objects conducive to probing weak and long-range interaction potentials in solution. (C) 2013 Optical Society of America
引用
收藏
页码：9377 / 9389
页数：13
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