FOX(M1) News-It Is Cancer

被引：190

作者：

Halasi, Marianna ^{[1
]}

Gartel, Andrei L. ^{[1
]}

机构：

[1] Univ Illinois, Dept Med, Chicago, IL 60612 USA

来源：

MOLECULAR CANCER THERAPEUTICS | 2013年 / 12卷 / 03期

关键词：

M1 TRANSCRIPTION FACTOR; GENE-EXPRESSION PROFILES; FACTOR FOXM1; UP-REGULATION; C-MYC; PROTEASOME INHIBITORS; DOWNSTREAM TARGET; OXIDATIVE STRESS; GASTRIC-CANCER; ER-ALPHA;

D O I：

10.1158/1535-7163.MCT-12-0712

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

FOXM1 is an oncogenic transcription factor of the Forkhead family and it has a well-defined role in cell proliferation and cell-cycle progression. Expression of FOXM1 is excluded in quiescent or differentiated cells, but its level is highly elevated in proliferating and malignant cells. Overexpression of FOXM1 has been reported in more than 20 types of human cancer. In recent years, FOXM1 has been implicated in diverse cellular processes and also a growing body of experimental data has underlined the relevance of FOXM1 in tumorigenesis. Although FOXM1 is under the control of three major tumor suppressors (RB, p53, and p19(ARF)), it is still active in the majority of human cancers. The oncogenic potential of FOXM1 is mainly based on its ability to transcriptionally activate genes that are involved in different facets of cancer development. In this review, the contribution of FOXM1 to each of the hallmarks of cancer will be summarized and discussed. Mol Cancer Ther; 12(3); 245-54. (C)2012 AACR.

引用

页码：245 / 254

页数：10

共 82 条

[1] Protein Phosphatase 2A (B55α) Prevents Premature Activation of Forkhead Transcription Factor FoxM1 by Antagonizing Cyclin A/Cyclin-dependent Kinase-mediated Phosphorylation [J].

Alvarez-Fernandez, Monica ;

Halim, Vincentius A. ;

Aprelia, Melinda ;

Mohammed, Shabaz ;

Medema, Rene H. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (38) :33029-33036

[2] A Systematic Screen for CDK4/6 Substrates Links FOXM1 Phosphorylation to Senescence Suppression in Cancer Cells [J].

Anders, Lars ;

Ke, Nan ;

Hydbring, Per ;

Choi, Yoon J. ;

Widlund, Hans R. ;

Chick, Joel M. ;

Zhai, Huili ;

Vidal, Marc ;

Gygi, Stephen P. ;

Braun, Pascal ;

Sicinski, Piotr .

CANCER CELL, 2011, 20 (05) :620-634

[3] Foxm1 transcription factor is required for macrophage migration during lung inflammation and tumor formation [J].

Balli, D. ;

Ren, X. ;

Chou, F-S ;

Cross, E. ;

Zhang, Y. ;

Kalinichenko, V. V. ;

Kalin, T. V. .

ONCOGENE, 2012, 31 (34) :3875-3888

[4] Endothelial Cell-Specific Deletion of Transcription Factor FoxM1 Increases Urethane-Induced Lung Carcinogenesis [J].

Balli, David ;

Zhang, Yufang ;

Snyder, Jonathan ;

Kalinichenko, Vladimir V. ;

Kalin, Tanya V. .

CANCER RESEARCH, 2011, 71 (01) :40-50

[5] RETRACTED: Over-Expression of FoxM1 Leads to Epithelial-Mesenchymal Transition and Cancer Stem Cell Phenotype in Pancreatic Cancer Cells (Retracted article. See vol. 117, pg. 1963, 2016) [J].

Bao, Bin ;

Wang, Zhiwei ;

Ali, Shadan ;

Kong, Dejuan ;

Banerjee, Sanjeev ;

Ahmad, Aamir ;

Li, Yiwei ;

Azmi, Asfar S. ;

Miele, Lucio ;

Sarkar, Fazlul H. .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2011, 112 (09) :2296-2306

[6] Pro-proliferative FoxM1 is a target of p53-mediated repression [J].

Barsotti, A. M. ;

Prives, C. .

ONCOGENE, 2009, 28 (48) :4295-4305

[7] Phenotype-assisted transcriptome analysis identifies FOXM1 downstream from Ras-MKK3-p38 to regulate in vitro cellular invasion [J].

Behren, A. ;

Muehlen, S. ;

Sanhueza, G. A. Acuna ;

Schwager, C. ;

Plinkert, P. K. ;

Huber, P. E. ;

Abdollahi, A. ;

Simon, C. .

ONCOGENE, 2010, 29 (10) :1519-1530

[8] Integrated genomic analyses of ovarian carcinoma [J].

Bell, D. ;

Berchuck, A. ;

Birrer, M. ;

Chien, J. ;

Cramer, D. W. ;

Dao, F. ;

Dhir, R. ;

DiSaia, P. ;

Gabra, H. ;

Glenn, P. ;

Godwin, A. K. ;

Gross, J. ;

Hartmann, L. ;

Huang, M. ;

Huntsman, D. G. ;

Iacocca, M. ;

Imielinski, M. ;

Kalloger, S. ;

Karlan, B. Y. ;

Levine, D. A. ;

Mills, G. B. ;

Morrison, C. ;

Mutch, D. ;

Olvera, N. ;

Orsulic, S. ;

Park, K. ;

Petrelli, N. ;

Rabeno, B. ;

Rader, J. S. ;

Sikic, B. I. ;

Smith-McCune, K. ;

Sood, A. K. ;

Bowtell, D. ;

Penny, R. ;

Testa, J. R. ;

Chang, K. ;

Dinh, H. H. ;

Drummond, J. A. ;

Fowler, G. ;

Gunaratne, P. ;

Hawes, A. C. ;

Kovar, C. L. ;

Lewis, L. R. ;

Morgan, M. B. ;

Newsham, I. F. ;

Santibanez, J. ;

Reid, J. G. ;

Trevino, L. R. ;

Wu, Y. -Q. ;

Wang, M. .

NATURE, 2011, 474 (7353) :609-615

[9] Nucleophosmin Interacts with FOXM1 and Modulates the Level and Localization of FOXM1 in Human Cancer Cells [J].

Bhat, Uppoor G. ;

Jagadeeswaran, Ramasamy ;

Halasi, Marianna ;

Gartel, Andrei L. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (48) :41425-41433

[10] FoxM1 Is a General Target for Proteasome Inhibitors [J].

Bhat, Uppoor G. ;

Halasi, Marianna ;

Gartel, Andrei L. .

PLOS ONE, 2009, 4 (08)

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