FOX(M1) News-It Is Cancer

被引：188
作者：
Halasi, Marianna [1 ]
Gartel, Andrei L. [1 ]
机构：
[1] Univ Illinois, Dept Med, Chicago, IL 60612 USA
来源：
MOLECULAR CANCER THERAPEUTICS | 2013年 / 12卷 / 03期
关键词：
M1 TRANSCRIPTION FACTOR; GENE-EXPRESSION PROFILES; FACTOR FOXM1; UP-REGULATION; C-MYC; PROTEASOME INHIBITORS; DOWNSTREAM TARGET; OXIDATIVE STRESS; GASTRIC-CANCER; ER-ALPHA;
D O I：
10.1158/1535-7163.MCT-12-0712
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
FOXM1 is an oncogenic transcription factor of the Forkhead family and it has a well-defined role in cell proliferation and cell-cycle progression. Expression of FOXM1 is excluded in quiescent or differentiated cells, but its level is highly elevated in proliferating and malignant cells. Overexpression of FOXM1 has been reported in more than 20 types of human cancer. In recent years, FOXM1 has been implicated in diverse cellular processes and also a growing body of experimental data has underlined the relevance of FOXM1 in tumorigenesis. Although FOXM1 is under the control of three major tumor suppressors (RB, p53, and p19(ARF)), it is still active in the majority of human cancers. The oncogenic potential of FOXM1 is mainly based on its ability to transcriptionally activate genes that are involved in different facets of cancer development. In this review, the contribution of FOXM1 to each of the hallmarks of cancer will be summarized and discussed. Mol Cancer Ther; 12(3); 245-54. (C)2012 AACR.
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收藏
页码：245 / 254
页数：10
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