Discovery of the novel HLA-DRB1*10:04 allele in a Taiwanese volunteer bone marrow donor and identification of the probable HLA-A, -B, -C and-DRB1 haplotype in association with DRB1*10:04

被引：17
作者：
Yang, K. L. [1 ,2 ,3 ,4 ]
Lee, S. K. [1 ,2 ,3 ]
Kao, R. H. [1 ,2 ,3 ]
Lin, C. L. [1 ,2 ,3 ]
Lin, P. Y. [1 ,2 ,3 ]
机构：
[1] Buddhist Tzu Chi Gen Hosp, Immunogenet Lab, Buddhist Compass Relief Tzu Chi Fdn, Hualien 970, Taiwan
[2] Buddhist Tzu Chi Gen Hosp, Cord Blood Bank, Buddhist Tzu Chi Stem Cells Ctr, Buddhist Compass Relief Tzu Chi Fdn, Hualien 970, Taiwan
[3] Buddhist Tzu Chi Gen Hosp, Marrow Donor Registry, Buddhist Compass Relief Tzu Chi Fdn, Hualien 970, Taiwan
[4] Buddhist Tzu Chi Univ, Dept Med Biotechnol, Buddhist Compass Relief Tzu Chi Fdn, Hualien, Taiwan
来源：
INTERNATIONAL JOURNAL OF IMMUNOGENETICS | 2012年 / 39卷 / 05期
关键词：
POPULATION; HLA-DRB1; REGISTRY;
D O I：
10.1111/j.1744-313X.2012.01106.x
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We report here a novel variant of HLA-DRB1*10, DRB1*10:04, discovered in a Taiwanese volunteer bone marrow donor by a sequence-based typing (SBT) method. The DNA sequence of DRB1*10:04 differs from DRB1*10:01:01, in exon 2, at nucleotide positions 296 (G?A) and 303 (T?G). The nucleotide changes caused an amino acid substitution at amino acid residue 70 (R?Q). We hypothesize that the formation of DRB1*10:04 was probably the result of a gene recombination event where DRB1*10:01:01 received a minimum length of DNA sequence from DRB1*04:05:01, as the sequence of DRB1*10:04 is identical to DRB1*10:01:01 in exon 2 except the sequence from nucleotide 296 to nucleotide 303, which is identical to DRB1*04:05:01. The plausible HLA-A, -B, -C and -DRB1 haplotypes in association with DRB1*10:04 was deduced as A*01:01-B*37:01-C*06:02-DRB1*10:04.
引用
收藏
页码：448 / 450
页数：3
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