Kinetic study of succinic acid production by Actinobacillus succinogenes ZT-130

被引：83

作者：

Corona-Gonzalez, Rosa Isela ^{[1
]}

Bories, Andre ^{[2
]}

Gonzalez-Alvarez, Victor ^{[1
]}

Pelayo-Ortiz, Carlos ^{[1
]}

机构：

[1] Univ Guadalajara, Ctr Univ Ciencias Exactas & Ingn, Lab Biotecnol, Guadalajara 44430, Jalisco, Mexico

[2] INRA, Unite Expt Pech Rouge, Gruissan 11430, France

来源：

PROCESS BIOCHEMISTRY | 2008年 / 43卷 / 10期

关键词：

succinic acid; Actinobacillus succinogenes; inhibitory effect; glucose concentration; kinetic study; acid mixture concentration;

D O I：

10.1016/j.procbio.2008.05.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of different glucose concentrations (10-100 g/l) on succinic acid production by Actinobacillus succinogenes was studied. The maximum succinic acid concentration obtained was 33.8 g/l from 54.7 g/l of glucose. Productivities, conversion yields, and specific rates decreased when the amount of initial glucose was increased. The growth stopped with 22 g/l of acid mixture produced (succinic, formic, and acetic acids) and succinic acid production stopped with 45 g/l of acid mixture produced. These results point to a double inhibitory effect by glucose and products on growth and succinic acid production. The inhibition phenomenon was adequately described by Jerusalimsky equations for specific rate of growth and specific rate of succinic acid production. These expressions helped to quantify substrate and product inhibition effects. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1047 / 1053

页数：7

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