Risk of type 2 diabetes mellitus associated with plasma lipid levels: The rural Chinese cohort study

被引：33

作者：

Zhang, Ming ^{[1
]}

Zhou, Junmei ^{[1
]}

Liu, Yu ^{[2
]}

Sun, Xizhuo ^{[2
]}

Luo, Xinping ^{[1
]}

Han, Chengyi ^{[1
,3
]}

Zhang, Lu ^{[1
,3
]}

Wang, Bingyuan ^{[1
,3
]}

Ren, Yongcheng ^{[1
,3
]}

Zhao, Yang ^{[1
,3
]}

Zhang, Dongdong ^{[1
,3
]}

Liu, Xuejiao ^{[1
,3
]}

Hu, Dongsheng ^{[1
]}

机构：

[1] Shenzhen Univ, Hlth Sci Ctr, Dept Prevent Med, 3688 Nanhai Ave, Shenzhen 518060, Guangdong, Peoples R China

[2] Shenzhen Univ, Hlth Sci Ctr, Affiliated Luohu Hosp, 47 Youyi Rd, Shenzhen 518001, Guangdong, Peoples R China

[3] Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Hlth Stat, 100 Kexue Ave, Zhengzhou 450001, Henan, Peoples R China

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2018年 / 135卷

基金：

中国国家自然科学基金;

关键词：

Type 2 diabetes mellitus; Plasma lipid levels; Cohort study; DENSITY-LIPOPROTEIN-CHOLESTEROL; TRIGLYCERIDE; UTILITY; OBESITY; INDEX; RATIO;

D O I：

10.1016/j.diabres.2017.11.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: To investigate the association of type 2 diabetes mellitus (T2DM) risk and plasma lipid levels in rural Chinese. Methods: Each lipid variable was divided into quartiles and dichotomized by clinical cutoff points. Cox proportional-hazards model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of T2DM risk and plasma lipid levels and explore the interaction between plasma lipid levels and other risk factors. Results: 11,929 participants were included in the analysis. We documented 720 incident cases of T2DM over 70,720.84 person-years of follow-up, for an incidence of 10.18/1,000 person-years. In the multivariable-adjusted model, risk of T2DM was increased with the highest versus lowest quartiles of total cholesterol (TC) and triglycerides (TG) levels and TC/high-density lipoprotein-cholesterol (HDL-C) and TG/HDL-C ratios. The HRs (95% CIs) for the fourth quartiles, for example, were 1.34 (1.03-1.74), 2.32 (1.73-3.13), 1.66 (1.23-2.25), and 1.84 (1.38-2.45), respectively. In addition, risk of T2DM was increased with high TG level and TC/HDL-C and TG/HDL-C ratios by clinical cutoffs. The HRs (95% CIs) were 1.50 (1.25-1.80), 1.24 (1.03-1.48), and 1.44 (1.18-1.75), respectively. Risk of T2DM was associated with interactions between all lipid variables and age and BMI. TG level and TG/HDL-C ratio additionally interacted with gender (all P-interaction < 0.0001). Conclusions: Risk of T2DM was increased with elevated serum levels of TC and TG and TC/HDL-C and TG/HDL-C ratios and also with interactions between high TC and TG levels and TC/HDL-C and TG/HDL-C ratios and age and BMI in a rural Chinese population. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：150 / 157

页数：8