Timing and nature of reconstructive surgery for disorders of sex development - Introduction

被引:52
作者
Creighton, Sarah [3 ]
Chernausek, Steven D. [2 ]
Romao, Rodrigo [5 ,6 ]
Ransley, Philip [4 ]
Salle, Joao Pippi [1 ]
机构
[1] Univ Toronto, Hosp Sick Children, Toronto, ON M5G 1X8, Canada
[2] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Oklahoma City, OK 73190 USA
[3] Univ Coll London Hosp, London, England
[4] Great Ormond St Hosp Sick Children, London, England
[5] Dalhousie Univ, Dept Surg, IWK Hlth Ctr, Halifax, NS B3H 4H2, Canada
[6] Dalhousie Univ, Dept Urol, IWK Hlth Ctr, Halifax, NS, Canada
关键词
Disorders of sex development; Feminizing genitoplasty; Clitoroplasty; Vaginoplasty; Gonadal surgery; Timing; Technique; Multidisciplinary team approach; CONGENITAL ADRENAL-HYPERPLASIA; UROGENITAL SINUS MOBILIZATION; FEMINIZING GENITOPLASTY; HYPOSPADIAS REPAIR; 21-HYDROXYLASE DEFICIENCY; TRANSANORECTAL APPROACH; WOMEN; CLITOROPLASTY; INTERSEX; OUTCOMES;
D O I
10.1016/j.jpurol.2012.10.001
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The ideal timing and nature of surgical reconstruction in individuals with Disorders of Sex Development (DSD) is highly controversial. Despite the increasing number of publications on this topic, evidence-based recommendations still cannot be made. However it is generally accepted that optimal care for DSD requires an experienced multidisciplinary team. This means that surgical decisions are now made within the context of a multidisciplinary team and all members of the team e and not just specialist surgeons e may be called upon to discuss choices for surgery with patients and parents. To do this well, every clinician in the team should have an understanding of the range of techniques available for genital surgery, the risks and benefits of procedures and the controversies surrounding timing of surgery. The aim of this paper is to give an overview of the variety of surgical procedures in current use and in what situation a particular technique would be indicated. The short-term risks and benefits are described and where available long-term outcome data is discussed. To date, discussions surrounding genital surgery have been led primarily by surgeons. Some nonsurgical clinicians have expressed unease about decision making in genital surgery but have felt ill equipped to comment on an area with which they are unfamiliar. This review gives a detailed explanation of current surgical practice offered in a specialized center for DSD and such information should facilitate a more balanced discussion. (C) 2012 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:602 / 610
页数:9
相关论文
共 48 条
  • [31] Type of mutation and surgical procedure affect long-term quality of life for women with congenital adrenal hyperplasia
    Nordenskjoeld, Agneta
    Holmdahl, Gundela
    Frisen, Louise
    Falhammar, Henrik
    Filipsson, Helena
    Thoren, Marja
    Janson, Per Olof
    Hagenfeldt, Kerstin
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (02) : 380 - 386
  • [32] Sexual Function and Surgical Outcome in Women with Congenital Adrenal Hyperplasia Due to CYP21A2 Deficiency: Clinical Perspective and the Patients' Perception
    Nordenstrom, Anna
    Frisen, Louise
    Falhammar, Henrik
    Filipsson, Helena
    Holmdahl, Gundela
    Janson, Per Olof
    Thoren, Marja
    Hagenfeldt, Kerstin
    Nordenskjold, Agneta
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (08) : 3633 - 3640
  • [33] Proximal Hypospadias Repair Outcomes in Patients with a Specific Disorder of Sexual Development Diagnosis
    Palmer, Blake W.
    Reiner, William
    Kropp, Brad P.
    [J]. ADVANCES IN UROLOGY, 2012, 2012
  • [34] Total and Partial Urogenital Mobilization: Focus on Urinary Continence
    Palmer, Blake W.
    Trojan, Brandon
    Griffin, Katie
    Reiner, William
    Wisniewski, Amy
    Frimberger, Dominic
    Kropp, Bradley P.
    [J]. JOURNAL OF UROLOGY, 2012, 187 (04) : 1422 - 1426
  • [35] Puberty in subjects with complete androgen insensitivity syndrome
    Papadimitriou, DT
    Linglart, A
    Morel, Y
    Chaussain, JL
    [J]. HORMONE RESEARCH, 2006, 65 (03) : 126 - 131
  • [36] Total urogenital mobilization - An easier way to repair cloacas
    Pena, A
    [J]. JOURNAL OF PEDIATRIC SURGERY, 1997, 32 (02) : 263 - 268
  • [37] TRANSANORECTAL APPROACH FOR THE TREATMENT OF UROGENITAL SINUS - PRELIMINARY-REPORT
    PENA, A
    FILMER, B
    BONILLA, E
    MENDEZ, M
    STOLAR, C
    [J]. JOURNAL OF PEDIATRIC SURGERY, 1992, 27 (06) : 681 - 685
  • [38] Pippi Salle JL, 2012, CAN UROL ASS J S1, V6, pS48
  • [39] Pippi Salle JL, 2012, J UROL, P18
  • [40] Rink R C, 2006, J Pediatr Urol, V2, P351, DOI 10.1016/j.jpurol.2006.04.002