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Toxicokinetics of Deltamethrin: Dosage Dependency, Vehicle Effects, and Low-Dose Age-Equivalent Dosimetry in Rats
被引:22
作者:

Mortuza, Tanzir
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Coll Pharm, Athens, GA 30602 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Coll Pharm, Athens, GA 30602 USA

Chen, Chen
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Coll Pharm, Athens, GA 30602 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Coll Pharm, Athens, GA 30602 USA

White, Catherine A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Coll Pharm, Athens, GA 30602 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Coll Pharm, Athens, GA 30602 USA

Cummings, Brian S.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Coll Pharm, Athens, GA 30602 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Coll Pharm, Athens, GA 30602 USA

Muralidhara, Srinivasa
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h-index: 0
机构:
Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Coll Pharm, Athens, GA 30602 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Coll Pharm, Athens, GA 30602 USA

Gullick, Darren
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Coll Pharm, Athens, GA 30602 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Coll Pharm, Athens, GA 30602 USA

Bruckner, James V.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Coll Pharm, Athens, GA 30602 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Coll Pharm, Athens, GA 30602 USA
机构:
[1] Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Coll Pharm, Athens, GA 30602 USA
关键词:
deltamethrin;
pyrethroid;
toxicokinetics;
dosimetry;
risk;
children;
IN-VITRO METABOLISM;
PYRETHROID INSECTICIDES;
TISSUE DISTRIBUTION;
RISK-ASSESSMENT;
MOTOR FUNCTION;
ACUTE TOXICITY;
PLASMA;
EXPOSURE;
PERMETHRIN;
HEALTH;
D O I:
10.1093/toxsci/kfx260
中图分类号:
R99 [毒物学(毒理学)];
学科分类号:
100405 ;
摘要:
There is increasing concern that infants and children may be at increased risk of neurological effects of pyrethroids, the most widely used class of insecticide. The objectives of this investigation were to (1) characterize the dose-dependent toxicokinetics (TK) of deltamethrin (DLM) for exposures ranging from environmentally relevant to acutely toxic; (2) determine the influence of an aqueous versus oil vehicle on oral absorption and bioavailability; and (3) determine whether DLM exhibits low-dose, age-equivalent internal dosimetry. Serial arterial plasma samples were obtained for 72 h from adult, male Sprague Dawley rats given 0.05-5.0mg DLM/kg as an oral bolus in corn oil (CO). DLM exhibited linear, absorption rate-limited TK. Increases in maximumplasma concentration (C-max) and AUC(degrees)(infinity) were directly proportional to the dose. Oral bioavailability was quite limited. The vehicle and its volume had modest effect on the rate and extent of systemic absorption in adult rats. Postnatal day (PND) 15, 21, and 90 (adult) rats received 0.10, 0.25, or 0.50 mg DLM/kg orally in CO and were sacrificed periodically for plasma, brain, and liver collection. Age-dependent differences between PND 15 and 90 plasma C-max and AUC(degrees)(24) values progressively diminished as the dose decreased, but there was a lack of low dose age equivalence in these brain and liver dosimeters. Other maturational factors may account for the lack of the low-dose age equivalence in brain and liver. This investigation provides support for the premise that the relatively low metabolic capacity of immature subjects may be adequate to effectively eliminate trace amounts of DLM and other pyrethroids from the plasma.
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页码:327 / 336
页数:10
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共 49 条
- [1] Influence of Maturation on In Vivo Tissue to Plasma Partition Coefficients for Cis- and Trans-Permethrin[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 106 (08) : 2144 - 2151Amaraneni, Manoj论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USAPang, Jing论文数: 0 引用数: 0 h-index: 0机构: Chinese Acad Med Sci, Inst Med Biotechnol, Beijing, Peoples R China Peking Union Med Coll, Beijing, Peoples R China Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USABruckner, James V.论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USAMuralidhara, Srinivasa论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USAMortuza, Tanzir B.论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USAGullick, Darren论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USAHooshfar, Shirin论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USAWhite, Catherine A.论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USACummings, Brian S.论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA
- [2] Brain uptake of deltamethrin in rats as a function of plasma protein binding and blood-brain barrier maturation[J]. NEUROTOXICOLOGY, 2017, 62 : 24 - 29Amaraneni, Manoj论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA Univ Cincinnati, Coll Med, Div Neurol, Cincinnati Childrens Res Fdn, Cincinnati, OH 45220 USA Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45220 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USAPang, Jing论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA Univ Cincinnati, Coll Med, Div Neurol, Cincinnati Childrens Res Fdn, Cincinnati, OH 45220 USA Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45220 USA Chinese Acad Med Sci, Peking Union Med Coll, Inst Med Biotechnol, Beijing, Peoples R China Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USAMortuza, Tanzir B.论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA Univ Cincinnati, Coll Med, Div Neurol, Cincinnati Childrens Res Fdn, Cincinnati, OH 45220 USA Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45220 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USAMuralidhara, Srinivasa论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA Univ Cincinnati, Coll Med, Div Neurol, Cincinnati Childrens Res Fdn, Cincinnati, OH 45220 USA Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45220 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USACummings, Brian S.论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA Univ Cincinnati, Coll Med, Div Neurol, Cincinnati Childrens Res Fdn, Cincinnati, OH 45220 USA Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45220 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USAWhite, Catherine A.论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA Univ Cincinnati, Coll Med, Div Neurol, Cincinnati Childrens Res Fdn, Cincinnati, OH 45220 USA Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45220 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USAVorhees, Charles V.论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA Univ Cincinnati, Coll Med, Div Neurol, Cincinnati Childrens Res Fdn, Cincinnati, OH 45220 USA Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45220 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USAZastre, Jason论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA Univ Cincinnati, Coll Med, Div Neurol, Cincinnati Childrens Res Fdn, Cincinnati, OH 45220 USA Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45220 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USABruckner, James V.论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA Univ Cincinnati, Coll Med, Div Neurol, Cincinnati Childrens Res Fdn, Cincinnati, OH 45220 USA Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45220 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA
- [3] TOXICOKINETICS OF PERMETHRIN IN THE RAT[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 1991, 110 (01) : 1 - 8ANADON, A论文数: 0 引用数: 0 h-index: 0MARTINEZLARRANAGA, MR论文数: 0 引用数: 0 h-index: 0DIAZ, MJ论文数: 0 引用数: 0 h-index: 0BRINGAS, P论文数: 0 引用数: 0 h-index: 0
- [4] Toxicokinetics of lambda-cyhalothrin in rats[J]. TOXICOLOGY LETTERS, 2006, 165 (01) : 47 - 56Anadon, A.论文数: 0 引用数: 0 h-index: 0机构: Univ Complutense Madrid, Fac Vet Med, Dept Toxicol & Pharmacol, Madrid 28040, Spain Univ Complutense Madrid, Fac Vet Med, Dept Toxicol & Pharmacol, Madrid 28040, SpainMartinez, M.论文数: 0 引用数: 0 h-index: 0机构: Univ Complutense Madrid, Fac Vet Med, Dept Toxicol & Pharmacol, Madrid 28040, Spain Univ Complutense Madrid, Fac Vet Med, Dept Toxicol & Pharmacol, Madrid 28040, SpainMartinez, M. A.论文数: 0 引用数: 0 h-index: 0机构: Univ Complutense Madrid, Fac Vet Med, Dept Toxicol & Pharmacol, Madrid 28040, Spain Univ Complutense Madrid, Fac Vet Med, Dept Toxicol & Pharmacol, Madrid 28040, SpainDiaz, M. J.论文数: 0 引用数: 0 h-index: 0机构: Univ Complutense Madrid, Fac Vet Med, Dept Toxicol & Pharmacol, Madrid 28040, Spain Univ Complutense Madrid, Fac Vet Med, Dept Toxicol & Pharmacol, Madrid 28040, SpainMartinez-Larranaga, M. R.论文数: 0 引用数: 0 h-index: 0机构: Univ Complutense Madrid, Fac Vet Med, Dept Toxicol & Pharmacol, Madrid 28040, Spain Univ Complutense Madrid, Fac Vet Med, Dept Toxicol & Pharmacol, Madrid 28040, Spain
- [5] Toxicokinetics of deltamethrin and its 4'-HO-metabolite in the rat[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 1996, 141 (01) : 8 - 16Anadon, A论文数: 0 引用数: 0 h-index: 0MartinezLarranaga, MR论文数: 0 引用数: 0 h-index: 0FernandezCruz, ML论文数: 0 引用数: 0 h-index: 0Diaz, MJ论文数: 0 引用数: 0 h-index: 0Fernandez, MC论文数: 0 引用数: 0 h-index: 0Martinez, MA论文数: 0 引用数: 0 h-index: 0
- [6] Characterization of deltamethrin metabolism by rat plasma and liver microsomes[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 2006, 212 (02) : 156 - 166Anand, SS论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USABruckner, JV论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USAHaines, WT论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USAMuralidhara, S论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USAFisher, JW论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USAPadilla, S论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA
- [7] Ontogeny of hepatic and plasma metabolism of deltamethrin in vitro: Role in age-dependent acute neurotoxicity[J]. DRUG METABOLISM AND DISPOSITION, 2006, 34 (03) : 389 - 397Anand, SS论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USAKim, KB论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USAPadilla, S论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USAMuralidhara, S论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USAKim, HJ论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USAFisher, JW论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USABruckner, JV论文数: 0 引用数: 0 h-index: 0机构: Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA
- [8] Urinary Concentrations of Metabolites of Pyrethroid Insecticides in the General US Population: National Health and Nutrition Examination Survey 1999-2002[J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 2010, 118 (06) : 742 - 748Barr, Dana Boyd论文数: 0 引用数: 0 h-index: 0机构: Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USAOlsson, Anders O.论文数: 0 引用数: 0 h-index: 0机构: Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USAWong, Lee-Yang论文数: 0 引用数: 0 h-index: 0机构: Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USAUdunka, Simeon论文数: 0 引用数: 0 h-index: 0机构: Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USABaker, Samuel E.论文数: 0 引用数: 0 h-index: 0机构: Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USAWhitehead, Ralph D., Jr.论文数: 0 引用数: 0 h-index: 0机构: Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USAMagsumbol, Melina S.论文数: 0 引用数: 0 h-index: 0机构: Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USAWilliams, Bryan L.论文数: 0 引用数: 0 h-index: 0机构: Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USANeedham, Larry L.论文数: 0 引用数: 0 h-index: 0机构: Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA
- [9] ACUTE TOXICITY OF 2 PYRETHROIDS, PERMETHRIN, AND CYPERMETHRIN IN NEONATAL AND ADULT-RATS[J]. ARCHIVES OF TOXICOLOGY, 1993, 67 (07) : 510 - 513CANTALAMESSA, F论文数: 0 引用数: 0 h-index: 0机构: Institute of Pharmacology, University of Camerino, Camerino, I-62032, MC
- [10] Effect of trihalomethanes on cell proliferation and DNA methylation in female B6C3F1 mouse liver[J]. TOXICOLOGICAL SCIENCES, 2000, 58 (02) : 243 - 252Coffin, JC论文数: 0 引用数: 0 h-index: 0机构: Med Coll Ohio, Dept Pathol, Toledo, OH 43614 USA Med Coll Ohio, Dept Pathol, Toledo, OH 43614 USAGe, RR论文数: 0 引用数: 0 h-index: 0机构: Med Coll Ohio, Dept Pathol, Toledo, OH 43614 USA Med Coll Ohio, Dept Pathol, Toledo, OH 43614 USAYang, SM论文数: 0 引用数: 0 h-index: 0机构: Med Coll Ohio, Dept Pathol, Toledo, OH 43614 USA Med Coll Ohio, Dept Pathol, Toledo, OH 43614 USAKramer, PM论文数: 0 引用数: 0 h-index: 0机构: Med Coll Ohio, Dept Pathol, Toledo, OH 43614 USA Med Coll Ohio, Dept Pathol, Toledo, OH 43614 USATao, LH论文数: 0 引用数: 0 h-index: 0机构: Med Coll Ohio, Dept Pathol, Toledo, OH 43614 USA Med Coll Ohio, Dept Pathol, Toledo, OH 43614 USAPereira, MA论文数: 0 引用数: 0 h-index: 0机构: Med Coll Ohio, Dept Pathol, Toledo, OH 43614 USA Med Coll Ohio, Dept Pathol, Toledo, OH 43614 USA