A Comprehensive Review of Tocilizumab in COVID-19 Acute Respiratory Distress Syndrome

被引：59
作者：
Khiali, Sajad [1 ]
Khani, Elnaz [1 ]
Entezari-Maleki, Taher [1 ,2 ]
机构：
[1] Tabriz Univ Med Sci, Dept Clin Pharm, Fac Pharm, Tabriz, Iran
[2] Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz, Iran
来源：
JOURNAL OF CLINICAL PHARMACOLOGY | 2020年 / 60卷 / 09期
关键词：
acute lung injury; ARDS; CRS; COVID-19; IL-6; SARS-CoV-2; tocilizumab; DRUG-METABOLIZING-ENZYMES; SARS-CORONAVIRUS; CYTOKINE STORM; RECEPTOR; IL-6; INTERLEUKIN-6; PATHOGENESIS; INFLAMMATION; PNEUMONIA; INFECTION;
D O I：
10.1002/jcph.1693
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Currently, the world is facing the pandemic of a novel strain of beta-coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Acute respiratory distress syndrome (ARDS) is the most devastating complication of SARS-CoV-2. It was indicated that cytokine-release syndrome and dominantly interleukin (IL)-6 play a central role in the pathophysiology of ARDS related to the novel 2019 coronavirus disease (COVID-19). Despite the global emergency of the disease, at this time, there are no proven therapies for the management of the disease. Tocilizumab is a potential recombinant monoclonal antibody against IL-6 and currently is under investigation for the management of ARDS in patients with COVID-19. Given these points, we reviewed the current evidence regarding the potential therapeutic role of tocilizumab and its important clinical issues in the treatment of ARDS related to COVID-19.
引用
收藏
页码：1131 / 1146
页数：16
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