Altered cortisol awakening response in posttraumatic stress disorder

被引:205
作者
Wessa, M
Rohleder, N
Kirschbaum, C
Flor, H
机构
[1] Heidelberg Univ, Cent Inst Mental Hlth, Dept Clin & Cognit Neurosci, D-68159 Mannheim, Germany
[2] Tech Univ Dresden, Dept Psychol, D-01069 Dresden, Germany
关键词
posttraumatic stress disorder; salivary cortisol; awakening response;
D O I
10.1016/j.psyneuen.2005.06.010
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
An altered function of the hypothalamic-pituitary-ad renal axis is assumed to be characteristic for Posttraumatic Stress Disorder (PTSD), although there is inconsistent empirical evidence. Only few studies examined the awakening cortisol response and a daytime profile in PTSD. Salivary cortisol Levels were measured at seven intervals from awakening until 8 PM in trauma-exposed subjects with (N=29) and without PTSD (N=19) and in 15 non-exposed controls. White the three groups did not differ with respect to their first cortisol level immediately after awakening, the expected cortisol increase to awakening 15-60 min Later was significantly Lower in PTSD patients compared to non-PTSD subjects and healthy controls. This effect remained stable when trauma-exposed subjects with comorbid major depression were excluded from the analysis. A significant negative correlation between the overall cortisol secretion (AUC(G)) and overall PTSD symptomatology and hyperarousal symptoms was found. The findings are discussed in tight of the hypothesis of a counterregulation of hyperarousal symptoms and chronic stress in PTSD. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码:209 / 215
页数:7
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