Change in Total Body Water as a Predictive Tool for Growth Hormone Treatment Response

被引:3
作者
Ernst, Manon A. B. [2 ,4 ]
Simons, Michelle Y. G. [1 ]
Gerver, Angele J. G. M. [1 ]
Zandwijken, Gladys R. J. [3 ]
Zimmermann, Luc J. I. [1 ]
Gerver, Willem-Jan M. [1 ]
机构
[1] Maastricht Univ Med Ctr, Dept Paediat, Sch Nutr Toxicol & Metab, NL-6202 AZ Maastricht, Netherlands
[2] Maastricht Univ Med Ctr, Dept Social Med, Sch Publ Hlth & Primary Care, NL-6202 AZ Maastricht, Netherlands
[3] Dutch Growth Res Fdn, Rotterdam, Netherlands
[4] Reg Publ Hlth Serv, S Limburg, Netherlands
来源
HORMONE RESEARCH IN PAEDIATRICS | 2012年 / 78卷 / 01期
关键词
Body composition; Growth hormone therapy; Growth hormone deficiency; Small for gestational age children; FOR-GESTATIONAL-AGE; BONE-MINERAL DENSITY; ENERGY-EXPENDITURE; SHORT CHILDREN; GH TREATMENT; 1ST YEAR;
D O I
10.1159/000339679
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background/Aims: To investigate whether short-term changes in body composition as a result of growth hormone therapy could be used to predict its growth effect after 1 year in children with growth hormone deficiency (GHD) and children born small for gestational age (SGA). Methods: 88 GHD children and 99 SGA children who started treatment with recombinant human growth hormone were included. Total body water (TBW) and height were measured. After 1 year, patients were divided into adequate and inadequate responders. Results: In GHD and SGA children a sensitivity of 87 and 53%, respectively, and a specificity of 58 and 83%, respectively, were found. The positive predictive values for GHD and SGA children were 73 and 90%, respectively. The negative predictive values were 75 and 32%, respectively. Conclusion: Changes in body composition data measured by TBW are a valuable tool to correctly predict 75% of the GHD children and are only useful in SGA children when the change in TBW is above the cut-off value of 0.7 l/m(2). Copyright (C) 2012 S. Karger AG, Basel
引用
收藏
页码:18 / 23
页数:6
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