Change in Total Body Water as a Predictive Tool for Growth Hormone Treatment Response

被引：3

作者：

Ernst, Manon A. B. ^{[2
,4
]}

Simons, Michelle Y. G. ^{[1
]}

Gerver, Angele J. G. M. ^{[1
]}

Zandwijken, Gladys R. J. ^{[3
]}

Zimmermann, Luc J. I. ^{[1
]}

Gerver, Willem-Jan M. ^{[1
]}

机构：

[1] Maastricht Univ Med Ctr, Dept Paediat, Sch Nutr Toxicol & Metab, NL-6202 AZ Maastricht, Netherlands

[2] Maastricht Univ Med Ctr, Dept Social Med, Sch Publ Hlth & Primary Care, NL-6202 AZ Maastricht, Netherlands

[3] Dutch Growth Res Fdn, Rotterdam, Netherlands

[4] Reg Publ Hlth Serv, S Limburg, Netherlands

来源：

HORMONE RESEARCH IN PAEDIATRICS | 2012年 / 78卷 / 01期

关键词：

Body composition; Growth hormone therapy; Growth hormone deficiency; Small for gestational age children; FOR-GESTATIONAL-AGE; BONE-MINERAL DENSITY; ENERGY-EXPENDITURE; SHORT CHILDREN; GH TREATMENT; 1ST YEAR;

D O I：

10.1159/000339679

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background/Aims: To investigate whether short-term changes in body composition as a result of growth hormone therapy could be used to predict its growth effect after 1 year in children with growth hormone deficiency (GHD) and children born small for gestational age (SGA). Methods: 88 GHD children and 99 SGA children who started treatment with recombinant human growth hormone were included. Total body water (TBW) and height were measured. After 1 year, patients were divided into adequate and inadequate responders. Results: In GHD and SGA children a sensitivity of 87 and 53%, respectively, and a specificity of 58 and 83%, respectively, were found. The positive predictive values for GHD and SGA children were 73 and 90%, respectively. The negative predictive values were 75 and 32%, respectively. Conclusion: Changes in body composition data measured by TBW are a valuable tool to correctly predict 75% of the GHD children and are only useful in SGA children when the change in TBW is above the cut-off value of 0.7 l/m(2). Copyright (C) 2012 S. Karger AG, Basel

引用

页码：18 / 23

页数：6

共 23 条

[1] Growth and body composition in very young SGA children [J].

Argente, Jesus ;

Mehls, Otto ;

Barrios, Vicente .

PEDIATRIC NEPHROLOGY, 2010, 25 (04) :679-685

[2] Changes in bone mineral density, body composition, and lipid metabolism during growth hormone (GH) treatment in children with GH deficiency [J].

Boot, AM ;

Engels, MAMJ ;

Boerma, GJM ;

Krenning, EP ;

KeizerSchrama, SMPFD .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (08) :2423-2428

[3]

Centraal Begeleidingsorgaan voor de Intercollegiale Toetsing, 1996, CONS DIAGN KLEIN LIC

[4] BODY COMPOSITION CHANGES IN CHILDREN RECEIVING HUMAN GROWTH-HORMONE [J].

COLLIPP, PJ ;

CURTI, V ;

THOMAS, J ;

SHARMA, RK ;

MADDAIAH, VT ;

COHN, SH .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1973, 22 (04) :589-595

[5] Growth hormone treatment of short children born small for gestational age [J].

de Zegher, F ;

Francois, I ;

van Helvoirt, M ;

Beckers, D ;

Ibáñez, L ;

Chatelain, P .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 1998, 9 (06) :233-237

[6]

Ernst MAB, 2012, BODY PROPORTIO UNPUB

[7]

Fredriks AM, 1997, THESIS LEIDEN, P258

[8]

Gerver W JM., 2001, Paediatric Morphometrics : A Reference Manual

[9] CHANGES IN BODY-COMPOSITION AND ENERGY-EXPENDITURE AFTER 6 WEEKS GROWTH-HORMONE TREATMENT [J].

GREGORY, JW ;

GREENE, SA ;

JUNG, RT ;

SCRIMGEOUR, CM ;

RENNIE, MJ .

ARCHIVES OF DISEASE IN CHILDHOOD, 1991, 66 (05) :598-602

[10] Body composition, atherogenic risk factors and apolipoproteins following growth hormone treatment [J].

Hassan, HMS ;

Kohno, H ;

Kuromaru, R ;

Honda, S ;

Ueda, K .

ACTA PAEDIATRICA, 1996, 85 (08) :899-901

← 1 2 3 →