Recent reviews and meta-analyses reported structural gray matter changes in patients suffering from adult-onset posttraumatic stress disorder (PTSD) and in subjects with and without PTSD who experienced childhood trauma. However, it remains unclear if such structural changes are also affecting the white matter. The aim of this systematic review is to provide a comprehensive overview of all empirical investigations measuring white matter integrity in populations affected by PTSD and/or childhood trauma. To this end, results from different methodological approaches were included. Twenty-five articles are reviewed of which 10 pertained to pediatric PTSD and the effects of childhood trauma measured during childhood, seven to the effects of childhood trauma measured during adulthood, and eight to adult-onset PTSD. Overall, reductions in white matter volume were reported more often than increases in these populations. However, the heterogeneity of the exact locations indicates only a weak overlap across published studies. In addition, a meta-analysis was carried out on seven whole-brain diffusion tensor imaging (DTI) studies in adults. Significant clusters of both increases and decreases were identified in various structures, most notably the cingulum and the superior longitudinal fasciculus. Future research directions are discussed.
机构:
McLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02178 USAHarvard Univ, Sch Med, McLean Hosp, Dept Psychiat, Belmont, MA 02478 USA
Andersen, Susan L.
Tomada, Akemi
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机构:
McLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02178 USAHarvard Univ, Sch Med, McLean Hosp, Dept Psychiat, Belmont, MA 02478 USA
Tomada, Akemi
Vincow, Evelyn S.
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h-index: 0
机构:
Univ Washington, Grad Program Neurobiol & Behavior, Seattle, WA 98195 USAHarvard Univ, Sch Med, McLean Hosp, Dept Psychiat, Belmont, MA 02478 USA
Vincow, Evelyn S.
Valente, Elizabeth
论文数: 0引用数: 0
h-index: 0
机构:
McLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02178 USAHarvard Univ, Sch Med, McLean Hosp, Dept Psychiat, Belmont, MA 02478 USA
Valente, Elizabeth
Polcari, Ann
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h-index: 0
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McLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02178 USAHarvard Univ, Sch Med, McLean Hosp, Dept Psychiat, Belmont, MA 02478 USA
Polcari, Ann
Teicher, Martin H.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, McLean Hosp, Dept Psychiat, Belmont, MA 02478 USA
McLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02178 USAHarvard Univ, Sch Med, McLean Hosp, Dept Psychiat, Belmont, MA 02478 USA
机构:Leiden Univ, Med Ctr, Dept Psychiat, NL-2333 ZA Leiden, Netherlands
Ayling, Elliot
Aghajani, Moji
论文数: 0引用数: 0
h-index: 0
机构:
Curium Leiden Univ, Med Ctr, Dept Child & Adolescent Psychiat, NL-2342 AK Oegstgeest, NetherlandsLeiden Univ, Med Ctr, Dept Psychiat, NL-2333 ZA Leiden, Netherlands
Aghajani, Moji
Fouche, Jean-Paul
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h-index: 0
机构:
Univ Cape Town, Dept Human Biol, ZA-7925 Cape Town, South Africa
Univ Cape Town, Dept Psychiat, ZA-7925 Cape Town, South Africa
Univ Stellenbosch, Dept Psychiat, ZA-7500 Cape Town, South AfricaLeiden Univ, Med Ctr, Dept Psychiat, NL-2333 ZA Leiden, Netherlands
Fouche, Jean-Paul
van der Wee, Nic
论文数: 0引用数: 0
h-index: 0
机构:
Leiden Univ, Med Ctr, Dept Psychiat, NL-2333 ZA Leiden, Netherlands
Leiden Univ, Med Ctr, Leiden Inst Brain & Cognit, NL-2333 ZA Leiden, NetherlandsLeiden Univ, Med Ctr, Dept Psychiat, NL-2333 ZA Leiden, Netherlands
机构:
McLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02478 USA
Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA
Catholic Univ Korea, Daejeon St Marys Hosp, Dept Psychiat, Taejon 301723, South KoreaMcLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02478 USA
Choi, Jeewook
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Jeong, Bumseok
Polcari, Ann
论文数: 0引用数: 0
h-index: 0
机构:
McLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02478 USA
Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USAMcLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02478 USA
Polcari, Ann
Rohan, Michael L.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA
McLean Hosp, Brain Imaging Ctr, Belmont, MA 02478 USAMcLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02478 USA
Rohan, Michael L.
Teicher, Martin H.
论文数: 0引用数: 0
h-index: 0
机构:
McLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02478 USA
Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USAMcLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02478 USA
机构:
McLean Hosp, DBRP, Belmont, MA 02478 USA
Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA
Catholic Univ Korea, Dept Psychiat, Daejeon St Marys Hosp, Taejon, South KoreaMcLean Hosp, DBRP, Belmont, MA 02478 USA
Choi, Jeewook
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Jeong, Bumseok
Rohan, Michael L.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA
McLean Hosp, Brain Imaging Ctr, Belmont, MA 02478 USAMcLean Hosp, DBRP, Belmont, MA 02478 USA
Rohan, Michael L.
Polcari, Ann M.
论文数: 0引用数: 0
h-index: 0
机构:
McLean Hosp, DBRP, Belmont, MA 02478 USA
Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USAMcLean Hosp, DBRP, Belmont, MA 02478 USA
Polcari, Ann M.
Teicher, Martin H.
论文数: 0引用数: 0
h-index: 0
机构:
McLean Hosp, DBRP, Belmont, MA 02478 USA
Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USAMcLean Hosp, DBRP, Belmont, MA 02478 USA
机构:
McLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02178 USAHarvard Univ, Sch Med, McLean Hosp, Dept Psychiat, Belmont, MA 02478 USA
Andersen, Susan L.
Tomada, Akemi
论文数: 0引用数: 0
h-index: 0
机构:
McLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02178 USAHarvard Univ, Sch Med, McLean Hosp, Dept Psychiat, Belmont, MA 02478 USA
Tomada, Akemi
Vincow, Evelyn S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Grad Program Neurobiol & Behavior, Seattle, WA 98195 USAHarvard Univ, Sch Med, McLean Hosp, Dept Psychiat, Belmont, MA 02478 USA
Vincow, Evelyn S.
Valente, Elizabeth
论文数: 0引用数: 0
h-index: 0
机构:
McLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02178 USAHarvard Univ, Sch Med, McLean Hosp, Dept Psychiat, Belmont, MA 02478 USA
Valente, Elizabeth
Polcari, Ann
论文数: 0引用数: 0
h-index: 0
机构:
McLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02178 USAHarvard Univ, Sch Med, McLean Hosp, Dept Psychiat, Belmont, MA 02478 USA
Polcari, Ann
Teicher, Martin H.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, McLean Hosp, Dept Psychiat, Belmont, MA 02478 USA
McLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02178 USAHarvard Univ, Sch Med, McLean Hosp, Dept Psychiat, Belmont, MA 02478 USA
机构:Leiden Univ, Med Ctr, Dept Psychiat, NL-2333 ZA Leiden, Netherlands
Ayling, Elliot
Aghajani, Moji
论文数: 0引用数: 0
h-index: 0
机构:
Curium Leiden Univ, Med Ctr, Dept Child & Adolescent Psychiat, NL-2342 AK Oegstgeest, NetherlandsLeiden Univ, Med Ctr, Dept Psychiat, NL-2333 ZA Leiden, Netherlands
Aghajani, Moji
Fouche, Jean-Paul
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cape Town, Dept Human Biol, ZA-7925 Cape Town, South Africa
Univ Cape Town, Dept Psychiat, ZA-7925 Cape Town, South Africa
Univ Stellenbosch, Dept Psychiat, ZA-7500 Cape Town, South AfricaLeiden Univ, Med Ctr, Dept Psychiat, NL-2333 ZA Leiden, Netherlands
Fouche, Jean-Paul
van der Wee, Nic
论文数: 0引用数: 0
h-index: 0
机构:
Leiden Univ, Med Ctr, Dept Psychiat, NL-2333 ZA Leiden, Netherlands
Leiden Univ, Med Ctr, Leiden Inst Brain & Cognit, NL-2333 ZA Leiden, NetherlandsLeiden Univ, Med Ctr, Dept Psychiat, NL-2333 ZA Leiden, Netherlands
机构:
McLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02478 USA
Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA
Catholic Univ Korea, Daejeon St Marys Hosp, Dept Psychiat, Taejon 301723, South KoreaMcLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02478 USA
Choi, Jeewook
论文数: 引用数:
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机构:
Jeong, Bumseok
Polcari, Ann
论文数: 0引用数: 0
h-index: 0
机构:
McLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02478 USA
Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USAMcLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02478 USA
Polcari, Ann
Rohan, Michael L.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA
McLean Hosp, Brain Imaging Ctr, Belmont, MA 02478 USAMcLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02478 USA
Rohan, Michael L.
Teicher, Martin H.
论文数: 0引用数: 0
h-index: 0
机构:
McLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02478 USA
Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USAMcLean Hosp, Dev Biopsychiat Res Program, Belmont, MA 02478 USA
机构:
McLean Hosp, DBRP, Belmont, MA 02478 USA
Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA
Catholic Univ Korea, Dept Psychiat, Daejeon St Marys Hosp, Taejon, South KoreaMcLean Hosp, DBRP, Belmont, MA 02478 USA
Choi, Jeewook
论文数: 引用数:
h-index:
机构:
Jeong, Bumseok
Rohan, Michael L.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA
McLean Hosp, Brain Imaging Ctr, Belmont, MA 02478 USAMcLean Hosp, DBRP, Belmont, MA 02478 USA
Rohan, Michael L.
Polcari, Ann M.
论文数: 0引用数: 0
h-index: 0
机构:
McLean Hosp, DBRP, Belmont, MA 02478 USA
Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USAMcLean Hosp, DBRP, Belmont, MA 02478 USA
Polcari, Ann M.
Teicher, Martin H.
论文数: 0引用数: 0
h-index: 0
机构:
McLean Hosp, DBRP, Belmont, MA 02478 USA
Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USAMcLean Hosp, DBRP, Belmont, MA 02478 USA