Immunomodulatory Agents in Follicular Lymphoma

被引：5

作者：

Ysebaert, Loic ^{[1
]}

Morschhauser, Franck ^{[2
]}

机构：

[1] IUC Toulouse Oncopole, Inst Univ Canc Toulouse Oncopole, INSERM, Serv Hematol,UMR1037,Ctr Canc Res Toulouse CRCT, 1 Ave Irene Joliot Curie, F-31059 Toulouse, France

[2] Univ Lille, CHU Lille, ULR 7365, GRITA Grp Rech Formes Injectables & Technol Assoc, Lille, France

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2020年 / 34卷 / 04期

关键词：

Chemo-free approaches; Follicular lymphoma; Immunomodulatory agents; Monoclonal antibodies; Tumor immune microenvironment; PHASE-II TRIAL; CELL; LENALIDOMIDE; RITUXIMAB; BLOCKADE; MICROENVIRONMENT; OBINUTUZUMAB; INHIBITION; EXPRESSION; SURVIVAL;

D O I：

10.1016/j.hoc.2020.02.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

New treatment strategies in follicular lymphoma (FL) are driven by a deeper understanding of microenvironmental cues supporting lymphomagenesis, chemoresistance, and immuno-escape. These immune-mediated signaling pathways contribute to initial learnings and clinical successes with lenalidomide, the first, oral, non-chemotherapeutic immunomodulatory drug, combined with anti-CD20 antibodies. This combination of lenalidomide with rituximab showed similar efficacy to chemoimmunotherapy (CIT) in first-line patients requiring therapy, and is approved in relapsed/refractory FL. We review the biology supporting the rationale for adequate inhibitory receptor/ligand pathways targeting the tissue immune microenvironment of FL cells, and potential immunomodulating combinations to replace CIT in the near future.

引用

页码：715 / +

页数：14

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