Polymorphism of the complement 5 gene is associated with large artery atherosclerosis stroke in Chinese patients

被引：0

作者：

Wu, Hui ^{[1
]}

Weng, Yingfeng ^{[1
]}

Zheng, Lan ^{[1
]}

Li, Huanyin ^{[1
]}

Gong, Qi ^{[1
]}

Fu, Yi ^{[2
]}

Zhao, Jing ^{[1
]}

机构：

[1] Minhang Dist Cent Hosp, Dept Neurol, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai 200030, Peoples R China

来源：

ARQUIVOS DE NEURO-PSIQUIATRIA | 2016年 / 74卷 / 11期

基金：

中国国家自然科学基金;

关键词：

genes; stroke; ACUTE ISCHEMIC-STROKE; DISEASE; RISK; RELIABILITY; ACTIVATION; OUTCOMES; HUMANS; SCALE; MICE;

D O I：

10.1590/0004-282X20160139

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The complement system has been confirmed to play an increasingly important role in ischemic stroke (IS). This study aimed to determine whether the single-nucleotide polymorphism of the complement 5 (C5) gene independently influences the occurrence, severity, and long-term outcome of IS in Chinese patients. Methods: C5 rs17611 genetic variants were investigated in 494 IS patients and 330 control individuals. Ischemic stroke was classified into subtypes and patients were assessed 90 days post-stroke with the modified Rankin Scale to determine stroke outcome. Results: The presence of C5 polymorphism was associated with the incidence of large artery atherosclerosis (LAA)-subtype IS (n = 2 00; p = 0.031), which even persisted after adjustment for covariates (OR = 1.518; 95% CI = 1.093-2.018; p = 0.013). However, no association was found between genotypes and the severity and outcome of stroke (p = 0.978; p = 0.296). Conclusions: The C5 polymorphism might contribute to the risk of LAA-subtype IS independently of other known risk predictors.

引用

页码：881 / 886

页数：6

共 23 条

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