The Study to Explore Early Development (SEED): A Multisite Epidemiologic Study of Autism by the Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) Network

被引：114

作者：

Schendel, Diana E. ^{[1
]}

DiGuiseppi, Carolyn ^{[2
]}

Croen, Lisa A. ^{[1
,3
]}

Fallin, M. Daniele ^{[4
]}

Reed, Philip L. ^{[5
]}

Schieve, Laura A.

Wiggins, Lisa D. ^{[1
]}

Daniels, Julie ^{[6
,7
]}

Grether, Judith ^{[8
]}

Levy, Susan E. ^{[9
]}

Miller, Lisa ^{[10
]}

Newschaffer, Craig ^{[11
]}

Pinto-Martin, Jennifer ^{[12
,13
]}

Robinson, Cordelia ^{[14
]}

Windham, Gayle C. ^{[8
]}

Alexander, Aimee ^{[1
]}

Aylsworth, Arthur S. ^{[15
,16
]}

Bernal, Pilar ^{[17
]}

Bonner, Joseph D. ^{[5
]}

Blaskey, Lisa ^{[9
]}

Bradley, Chyrise ^{[6
]}

Collins, Jack ^{[3
]}

Ferretti, Casara J. ^{[9
]}

Farzadegan, Homayoon ^{[4
]}

Giarelli, Ellen ^{[12
]}

Harvey, Marques ^{[1
]}

Hepburn, Susan ^{[14
]}

Herr, Matthew ^{[6
]}

Kaparich, Kristina ^{[14
]}

Landa, Rebecca ^{[19
,20
]}

Lee, Li-Ching ^{[4
]}

Levenseller, Brooke ^{[12
]}

Meyerer, Stacey ^{[4
]}

Rahbar, Mohammad H. ^{[18
]}

Ratchford, Andria ^{[10
]}

Reynolds, Ann ^{[14
]}

Rosenberg, Steven ^{[14
]}

Rusyniak, Julie ^{[19
,20
]}

Shapira, Stuart K. ^{[1
]}

Smith, Karen ^{[8
]}

Souders, Margaret ^{[12
]}

Thompson, Patrick Aaron ^{[5
]}

Young, Lisa ^{[12
]}

Yeargin-Allsopp, Marshalyn ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA 30333 USA

[2] Univ Colorado, Dept Epidemiol, Colorado Sch Publ Hlth, Denver, CO 80202 USA

[3] Kaiser Permanente No Calif, Div Res, Oakland, CA USA

[4] Johns Hopkins Univ, Dept Epidemiol, Bloomberg Sch Publ Hlth, Baltimore, MD USA

[5] Michigan State Univ, Clin & Translat Sci Inst, E Lansing, MI 48824 USA

[6] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA

[7] Univ N Carolina, Dept Maternal & Child Hlth, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA

[8] CA Dept Publ Hlth, Div Environm & Occupat Dis Control, Oakland, CA USA

[9] Childrens Hosp Philadelphia, Ctr Autism, Philadelphia, PA 19104 USA

[10] Colorado Dept Publ Hlth & Environm, Denver, CO USA

[11] Drexel Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Philadelphia, PA 19104 USA

[12] Univ Penn, Sch Nursing, Philadelphia, PA 19104 USA

[13] Sch Med, Philadelphia, PA USA

[14] Univ Colorado, Sch Med, Denver, CO USA

[15] Univ N Carolina, Sch Med, Dept Pediat, Chapel Hill, NC USA

[16] Univ N Carolina, Sch Med, Dept Genet, Chapel Hill, NC USA

[17] Kaiser Permanente No Calif, Autism Spectrum Disorders Ctr, San Jose Med Ctr, Oakland, CA USA

[18] Univ Texas Houston, Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci, Houston, TX USA

[19] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA

[20] Johns Hopkins Univ, Sch Med, Kennedy Krieger Inst, Baltimore, MD USA

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2012年 / 42卷 / 10期

关键词：

Autism; Epidemiology; Study methods; Risk factors; Phenotype; PERINATAL RISK-FACTORS; SOCIAL COMMUNICATION QUESTIONNAIRE; DIAGNOSTIC OBSERVATION SCHEDULE; HAZARDOUS AIR-POLLUTANTS; SPECTRUM DISORDERS; GASTROINTESTINAL SYMPTOMS; ENVIRONMENTAL-FACTORS; ASSISTED CONCEPTION; CHILDREN BORN; FOLLOW-UP;

D O I：

10.1007/s10803-012-1461-8

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

The Study to Explore Early Development (SEED), a multisite investigation addressing knowledge gaps in autism phenotype and etiology, aims to: (1) characterize the autism behavioral phenotype and associated developmental, medical, and behavioral conditions and (2) investigate genetic and environmental risks with emphasis on immunologic, hormonal, gastrointestinal, and sociodemographic characteristics. SEED uses a case-control design with population-based ascertainment of children aged 2-5 years with an autism spectrum disorder (ASD) and children in two control groups-one from the general population and one with non-ASD developmental problems. Data from parent-completed questionnaires, interviews, clinical evaluations, biospecimen sampling, and medical record abstraction focus on the prenatal and early postnatal periods. SEED is a valuable resource for testing hypotheses regarding ASD characteristics and causes.

引用

页码：2121 / 2140

页数：20

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