Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats

被引：205

作者：

Kehr, J. ^{[1
,2
]}

Ichinose, F. ^{[1
]}

Yoshitake, S. ^{[1
]}

Goiny, M. ^{[1
,2
]}

Sievertsson, T. ^{[1
]}

Nyberg, F. ^{[3
]}

Yoshitake, T. ^{[2
]}

机构：

[1] Pronexus Analyt AB, Karolinska Inst Sci Pk, S-17177 Stockholm, Sweden

[2] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden

[3] Uppsala Univ, Dept Pharmaceut Biosci, Div Biol Res Drug Dependence, Uppsala, Sweden

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2011年 / 164卷 / 08期

基金：

瑞典研究理事会;

关键词：

4-methylmethcathinone; cathinones; phenethylamines; 3; 4-methylenedioxymethamphetamine; microdialysis; dopamine; 5-HT; serotonin; legal highs; psychostimulants; 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; RELEASE; CATHINONE; RECEPTORS; SEROTONIN; 4-METHYLMETHCATHINONE; PHARMACOKINETICS; LOCOMOTOR; COCAINE; DRUGS;

D O I：

10.1111/j.1476-5381.2011.01499.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

BACKGROUND AND PURPOSE The designer drug 1-(4-methylphenyl)-2-methylaminopropan-1-one (4-methylmethcathinone, mephedrone) is reported to possess psychostimulant, entactogenic and hallucinogenic effects. The purpose of this study was to examine the effects of acute administration of mephedrone on extracellular levels of dopamine (DA) and 5-HT in the nucleus accumbens of awake rats and compare these effects with those induced by 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and amphetamine.

引用

页码：1949 / 1958

页数：10

共 58 条

[1] Guide to receptors and channels (GRAC), 3rd edition [J].

Alexander, Stephen P. H. ;

Mathie, Alistair ;

Peters, John A. .

BRITISH JOURNAL OF PHARMACOLOGY, 2008, 153 :S1-S209

[2]

[Anonymous], 2007, RAT BRAIN STEROTAXIC

[3]

[Anonymous], IRISH MED J

[4]

[Anonymous], 2006, ENCY SENSORS 6 STEVE

[5]

[Anonymous], 1999, MODERN TECHNIQUES NE

[6] Role of serotonin2A receptors in the D-amphetamine-induced release of dopamine:: comparison with previous data on α1b-adrenergic receptors [J].

Auclair, A ;

Blanc, G ;

Glowinski, J ;

Tassin, JP .

JOURNAL OF NEUROCHEMISTRY, 2004, 91 (02) :318-326

[7] In Vivo Effects of Amphetamine Analogs Reveal Evidence for Serotonergic Inhibition of Mesolimbic Dopamine Transmission in the Rat [J].

Baumann, Michael H. ;

Clark, Robert D. ;

Woolverton, William L. ;

Wee, Sunmee ;

Blough, Bruce E. ;

Rothman, Richard B. .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2011, 337 (01) :218-225

[8] NEURAL AND CARDIAC TOXICITIES ASSOCIATED WITH 3,4-METHYLENEDIOXYMETHAMPHETAMINE (MDMA) [J].

Baumann, Michael H. ;

Rothman, Richard B. .

NEW CONCEPTS OF PSYCHOSTIMULANTS INDUCED NEUROTOXICITY, 2009, 88 :257-296

[9] Effects of Dose and Route of Administration on Pharmacokinetics of (±)-3,4-Methylenedioxymethamphetamine in the Rat [J].

Baumann, Michael H. ;

Zolkowska, Dorota ;

Kim, Insook ;

Scheidweiler, Karl B. ;

Rothman, Richard B. ;

Huestis, Marilyn A. .

DRUG METABOLISM AND DISPOSITION, 2009, 37 (11) :2163-2170

[10]

Brandt SD, 2010, DRUG TEST ANAL

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