Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats

被引：204
作者：
Kehr, J. [1 ,2 ]
Ichinose, F. [1 ]
Yoshitake, S. [1 ]
Goiny, M. [1 ,2 ]
Sievertsson, T. [1 ]
Nyberg, F. [3 ]
Yoshitake, T. [2 ]
机构：
[1] Pronexus Analyt AB, Karolinska Inst Sci Pk, S-17177 Stockholm, Sweden
[2] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden
[3] Uppsala Univ, Dept Pharmaceut Biosci, Div Biol Res Drug Dependence, Uppsala, Sweden
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 2011年 / 164卷 / 08期
基金：
瑞典研究理事会;
关键词：
4-methylmethcathinone; cathinones; phenethylamines; 3; 4-methylenedioxymethamphetamine; microdialysis; dopamine; 5-HT; serotonin; legal highs; psychostimulants; 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; RELEASE; CATHINONE; RECEPTORS; SEROTONIN; 4-METHYLMETHCATHINONE; PHARMACOKINETICS; LOCOMOTOR; COCAINE; DRUGS;
D O I：
10.1111/j.1476-5381.2011.01499.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
BACKGROUND AND PURPOSE The designer drug 1-(4-methylphenyl)-2-methylaminopropan-1-one (4-methylmethcathinone, mephedrone) is reported to possess psychostimulant, entactogenic and hallucinogenic effects. The purpose of this study was to examine the effects of acute administration of mephedrone on extracellular levels of dopamine (DA) and 5-HT in the nucleus accumbens of awake rats and compare these effects with those induced by 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) and amphetamine.
引用
收藏
页码：1949 / 1958
页数：10
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