Microvascular complications of diabetes

被引：124
作者：
He, ZH [1 ]
King, GL [1 ]
机构：
[1] Harvard Univ, Sch Med, Joslin Diabet Ctr, Sect Vasc Cell Biol & Complicat, Boston, MA 02215 USA
来源：
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2004年 / 33卷 / 01期
关键词：
D O I：
10.1016/j.ecl.2003.12.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Several theories of the pathogenesis of microvascular complications of diabetes (diabetic retinopathy, nephropathy, and neuropathy) have been proposed: (1) generation of reactive oxygen species and oxidative stress, (2) activation of polyol pathway, (3) formation of advanced glycation end products, (4) induction of flux through the hexosamine pathway, (5) altered expression and action of growth factors, and (6) activation of protein kinase C. Based on these theories, specific interventions are feasible to prevent the development of diabetic complications even if satisfactory euglycemic control is not achieved.
引用
收藏
页码：215 / +
页数：26
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