Nuclease activity of [Cu(sulfathiazolato)2(benzimidazole)2]2MeOH.: Synthesis, properties and crystal structure

被引：32

作者：

González-Alvarez, M

Alzuet, G

Borrás, J

Macías, B

del Olmo, M

Liu-González, M

Sanz, F

机构：

[1] Univ Valencia, Dept Quim Inorgan, E-46100 Burjassot, Spain

[2] Univ Valencia, Dept Bioquim, E-46100 Burjassot, Spain

[3] Univ Valencia, Dept Termol, E-46100 Burjassot, Spain

[4] Univ Salamanca, Dept Quim Inorgan, Salamanca 37007, Spain

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2002年 / 89卷 / 1-2期

关键词：

Cu(sulfathiazolato)(2)(benzimidazole)(2)](2)MeOH; nuclease activity; copper (II); DNA; pUC18;

D O I：

10.1016/S0162-0134(01)00369-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The [Cu(sulfathiazolato)(2)(benzimidazole)(2)]2MeOH complex has been synthesised and characterised. It crystallises in the monoclinic system, space group C1cl, with unit cell dimensions a = 18.829(7) Angstrom, b = 12.206(3) Angstrom, c = 17.233(5) Angstrom, alpha = 90.06(2)degrees, beta = 97.28(3)degrees, gamma = 90.21(3)degrees and Z = 4. The geometry around the copper(II) ion is intermediate between tetrahedral and square planar. The complex produces cleavage of plasmid pUC18 in presence of reducing agents. The efficiency of cleavage reaction of the title compound with pUC18 and with different reducing agents follows the order ascorbate-H2O2>ascorbate>MPA>dithiothreitol>H2O2. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：29 / 35

页数：7

共 34 条

[1] COMPLETION AND REFINEMENT OF CRYSTAL-STRUCTURES WITH SIR92
ALTOMARE, A
CASCARANO, G
GIACOVAZZO, C
GUAGLIARDI, A
[J]. JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1993, 26 (pt 3) : 343 - 350
[2] [Anonymous], [No title captured]
[3] [Anonymous], 1994, WINEPR SIMF 1 25
[4] SYNTHESIS AND SPECTROSCOPIC AND MAGNETIC-PROPERTIES OF MIXED-LIGAND COMPLEXES OF COPPER(II) WITH IMIDAZOLE AND N-PROTECTED AMINO-ACIDS - CRYSTAL AND MOLECULAR-STRUCTURE OF BIS(HIPPURATO)BIS(IMIDAZOLE)COPPER(II)
ANTOLINI, L
BATTAGLIA, LP
CORRADI, AB
MARCOTRIGIANO, G
MENABUE, L
PELLACANI, GC
SALADINI, M
[J]. INORGANIC CHEMISTRY, 1982, 21 (04) : 1391 - 1395
[5] HALOCUPRATES(II) OF THE N-PHENYLPIPERAZINIUM MONOCATIONS AND DICATIONS - CRYSTAL AND MOLECULAR-STRUCTURE OF N-PHENYLPIPERAZINIUM TETRACHLOROCUPRATE(II) - CORRELATION OF THE ELECTRONIC-SPECTRUM VS DISTORTION OF THE CUCL42- ANIONS FROM TETRAHEDRAL SYMMETR
BATTAGLIA, LP
CORRADI, AB
MARCOTRIGIANO, G
MENABUE, L
PELLACANI, GC
[J]. INORGANIC CHEMISTRY, 1979, 18 (01) : 148 - 152
[6] COORDINATION BEHAVIOR OF SULFATHIAZOLE - CRYSTAL-STRUCTURE OF [CU(SULFATHIAZOLE)(PY)(3)CL] SUPEROXIDE-DISMUTASE ACTIVITY
CASANOVA, J
ALZUET, G
BORRAS, J
LATORRE, J
SANAU, M
[J]. JOURNAL OF INORGANIC BIOCHEMISTRY, 1995, 60 (03) : 219 - 230
[7] Spectroscopic, magnetic, and electrochemical studies of a dimeric N-substituted-sulfanilamide copper(II) complex. X-ray and molecular structure of the Cu-2(sulfathiazolato)(4) complex
Casanova, J
Alzuet, G
Latorre, J
Borras, J
[J]. INORGANIC CHEMISTRY, 1997, 36 (10) : 2052 - 2058
[8] Crystal structures and superoxide dismutase mimetic activity of [CuL(2)(Him)(2)]center dot MeOH and [CuL(2)(mim)(2)]center dot H2O [HL=4-amino-N-(thiazol-2-yl)benzenesulfonamide, Him equals imidazole, mim equals N-methylimidazole]
Casanova, J
Alzuet, G
Borras, J
Carugo, O
[J]. JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1996, (11): : 2239 - 2244
[9] Superoxide dismutase activity of ternary copper complexes of sulfathiazole and imidazole derivatives.: Synthesis and properties of [CuL2(R-Him)2] [HL=4-amino-N-(thiazol-2-yl)benzenesulfonamide, R-Him=4-methylimidazole, 4,4-dimethylimidazoline or 1,2-dimethylimidazole].: Crystal structure of [CuL2(4,4-dimethylimidazoline)2]
Casanova, J
Alzuet, G
Ferrer, S
Latorre, J
Ramírez, JA
Borrás, J
[J]. INORGANICA CHIMICA ACTA, 2000, 304 (02) : 170 - 177
[10] El Amrani F B, 2000, Met Based Drugs, V7, P365, DOI 10.1155/MBD.2000.365

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