Antibacterial activity of selected metabolites from Chilean lichen species against methicillin-resistant staphylococci

被引：16
作者：
Celenza, Giuseppe [1 ]
Segatore, Bernardetta [1 ]
Setacci, Domenico [1 ]
Perilli, Mariagrazia [1 ]
Brisdelli, Fabrizia [1 ]
Bellio, Pierangelo [1 ]
Piovano, Marisa [2 ]
Garbarino, Juan A. [2 ]
Amicosante, Gianfranco [1 ]
Nicoletti, Marcello [3 ]
机构：
[1] Univ Aquila, Dept Biomed Sci & Technol, I-67100 Laquila, Italy
[2] Univ Tecn Federico Santa Maria, Dept Chem, Valparaiso, Chile
[3] Univ Sapienza, Dept Environm Biol, Rome, Italy
来源：
NATURAL PRODUCT RESEARCH | 2013年 / 27卷 / 17期
关键词：
lichen secondary metabolites; methicillin-resistant staphylococci; antimicrobial resistance; antibacterial activity; ANTIMICROBIAL ACTIVITY; USNIC ACID; AUREUS; CONSTITUENTS; COMBINATION; VANCOMYCIN; ATRANORIN; EXTRACTS;
D O I：
10.1080/14786419.2012.730043
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The invitro antibacterial activities of eight compounds isolated from lichens, collected in several Southern regions of Chile (including Antarctica), were evaluated against methicillin-resistant clinical isolates strains of Staphylococcus aureus, Staphylococcus haemolyticus and Staphylococcus warneri. The minimum inhibitory concentrations, calculated in microdilution, were ranging from 8 mu gmL(-1) for sphaerophorin to 1024 mu gmL(-1) for fumarprotocetraric acid. These findings suggest, however, that the natural compounds from lichens are good candidates for the individuation of novel templates for the development of new antimicrobial agents or combinations of drugs for chemotherapy.
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收藏
页码：1528 / 1531
页数：4
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