The Shifting Paradigm of Prognostic Factors of Colorectal Liver Metastases: From Tumor-Centered to Host immune-Centered Factors

被引：15
作者：
Donadon, Matteo [1 ,2 ]
Lleo, Ana [2 ,3 ]
Di Tommaso, Luca [2 ,4 ]
Soldani, Cristiana [1 ]
Franceschini, Barbara [1 ]
Roncalli, Massimo [2 ,4 ]
Torzilli, Guido [1 ,2 ]
机构：
[1] Humanitas Clin & Res Ctr, Dept Hepatobiliary & Gen Surg, Rozzano, Italy
[2] Humanitas Univ, Dept Biomed Sci, Rozzano, Italy
[3] Humanitas Clin & Res Ctr, Dept Internal Med, Rozzano, Italy
[4] Humanitas Clin & Res Ctr, Dept Pathol, Rozzano, Italy
来源：
FRONTIERS IN ONCOLOGY | 2018年 / 8卷
关键词：
host immune system; colorectal liver metastases; colorectal cancer liver metastases; colorectal cancer; immune response; immunotherapy; ENDOTHELIAL GROWTH-FACTOR; SURGICAL MARGIN STATUS; LONG-TERM SURVIVAL; K-RAS MUTATIONS; HEPATIC RESECTION; T-CELLS; NATURAL-KILLER; PULMONARY METASTASES; SUPPRESSOR-CELLS; NK CELLS;
D O I：
10.3389/fonc.2018.00181
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The determinants of prognosis in patients with colorectal liver metastases (CLM) have been traditionally searched among the tumoral factors, either of the primary colorectal tumor or of the CLM. While many different scoring systems have been developed based on those clinic-pathological factors with disparate results, there has been the introduction of genetic biological markers that added a theranostic perspective. More recently, other important elements, such as those factors related to the host immune system, have been proposed as determinants of prognosis of CLM patients. In the present work, we review the current prognostic factors of CLM patients as well as the burgeoning shifting paradigm of prognostication that relies on the host immune system.
引用
收藏
页数：7
相关论文
共 109 条
[61]   Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability [J].
Mlecnik, Bernhard ;
Bindea, Gabriela ;
Angell, Helen K. ;
Maby, Pauline ;
Angelova, Mihaela ;
Tougeron, David ;
Church, Sarah E. ;
Lafontaine, Lucie ;
Fischer, Maria ;
Fredriksen, Tessa ;
Sasso, Maristella ;
Bilocq, Amelie M. ;
Kirilovsky, Amos ;
Obenauf, Anna C. ;
Hamieh, Mohamad ;
Berger, Anne ;
Bruneval, Patrick ;
Tuech, Jean-Jacques ;
Sabourin, Jean-Christophe ;
Le Pessot, Florence ;
Mauillon, Jacques ;
Rafii, Arash ;
Laurent-Puig, Pierre ;
Speicher, Michael R. ;
Trajanoski, Zlatko ;
Michel, Pierre ;
Sesbouee, Richard ;
Frebourg, Thierry ;
Pages, Franck ;
Valge-Archer, Viia ;
Latouche, Jean-Baptiste ;
Galon, Jerome .
IMMUNITY, 2016, 44 (03) :698-711
[62]   Histopathologic-Based Prognostic Factors of Colorectal Cancers Are Associated With the State of the Local Immune Reaction [J].
Mlecnik, Bernhard ;
Tosolini, Marie ;
Kirilovsky, Amos ;
Berger, Anne ;
Bindea, Gabriela ;
Meatchi, Tchao ;
Bruneval, Patrick ;
Trajanoski, Zlatko ;
Fridman, Wolf-Herman ;
Pages, Franck ;
Galon, Jerome .
JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (06) :610-618
[63]   Biomolecular Network Reconstruction Identifies T-Cell Homing Factors Associated With Survival in Colorectal Cancer [J].
Mlecnik, Bernhard ;
Tosolini, Marie ;
Charoentong, Pornpimol ;
Kirilovsky, Amos ;
Bindea, Gabriela ;
Berger, Anne ;
Camus, Matthieu ;
Gillard, Melanie ;
Bruneval, Patrick ;
Fridman, Wolf-Herman ;
Pages, Franck ;
Trajanoski, Zlatko ;
Galon, Jerome .
GASTROENTEROLOGY, 2010, 138 (04) :1429-1440
[64]   NF-κB Hyperactivation in Tumor Tissues Allows Tumor-Selective Reprogramming of the Chemokine Microenvironment to Enhance the Recruitment of Cytolytic T Effector Cells [J].
Muthuswamy, Ravikumar ;
Berk, Erik ;
Junecko, Beth Fallert ;
Zeh, Herbert J. ;
Zureikat, Amer H. ;
Normolle, Daniel ;
The Minh Luong ;
Reinhart, Todd A. ;
Bartlett, David L. ;
Kalinski, Pawel .
CANCER RESEARCH, 2012, 72 (15) :3735-3743
[65]   Histopathological prognostic factors influencing long-term prognosis after surgical resection for hepatic metastases from colorectal cancer [J].
Nagashima, I ;
Oka, T ;
Hamada, C ;
Naruse, K ;
Osada, T ;
Muto, T .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 1999, 94 (03) :739-743
[66]  
Naito Y, 1998, CANCER RES, V58, P3491
[67]   AGGRESSIVE REPEAT LIVER RESECTION FOR HEPATIC METASTASES OF COLORECTAL-CARCINOMA [J].
NAKAMURA, S ;
SAKAGUCHI, S ;
NISHIYAMA, R ;
SUZUKI, S ;
YOKOI, Y ;
BABA, S ;
MARO, H .
SURGERY TODAY, 1992, 22 (03) :260-264
[68]  
Nielsen HJ, 1999, J PATHOL, V189, P487, DOI 10.1002/(SICI)1096-9896(199912)189:4<487::AID-PATH484>3.0.CO
[69]  
2-I
[70]   HEPATIC RESECTION FOR COLORECTAL LIVER METASTASES - INFLUENCE ON SURVIVAL OF PREOPERATIVE FACTORS AND SURGERY FOR RECURRENCES IN 80 PATIENTS [J].
NORDLINGER, B ;
PARC, R ;
DELVA, E ;
QUILICHINI, MA ;
HANNOUN, L ;
HUGUET, C .
ANNALS OF SURGERY, 1987, 205 (03) :256-263
234567891011