The Shifting Paradigm of Prognostic Factors of Colorectal Liver Metastases: From Tumor-Centered to Host immune-Centered Factors

被引：15
作者：
Donadon, Matteo [1 ,2 ]
Lleo, Ana [2 ,3 ]
Di Tommaso, Luca [2 ,4 ]
Soldani, Cristiana [1 ]
Franceschini, Barbara [1 ]
Roncalli, Massimo [2 ,4 ]
Torzilli, Guido [1 ,2 ]
机构：
[1] Humanitas Clin & Res Ctr, Dept Hepatobiliary & Gen Surg, Rozzano, Italy
[2] Humanitas Univ, Dept Biomed Sci, Rozzano, Italy
[3] Humanitas Clin & Res Ctr, Dept Internal Med, Rozzano, Italy
[4] Humanitas Clin & Res Ctr, Dept Pathol, Rozzano, Italy
来源：
FRONTIERS IN ONCOLOGY | 2018年 / 8卷
关键词：
host immune system; colorectal liver metastases; colorectal cancer liver metastases; colorectal cancer; immune response; immunotherapy; ENDOTHELIAL GROWTH-FACTOR; SURGICAL MARGIN STATUS; LONG-TERM SURVIVAL; K-RAS MUTATIONS; HEPATIC RESECTION; T-CELLS; NATURAL-KILLER; PULMONARY METASTASES; SUPPRESSOR-CELLS; NK CELLS;
D O I：
10.3389/fonc.2018.00181
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The determinants of prognosis in patients with colorectal liver metastases (CLM) have been traditionally searched among the tumoral factors, either of the primary colorectal tumor or of the CLM. While many different scoring systems have been developed based on those clinic-pathological factors with disparate results, there has been the introduction of genetic biological markers that added a theranostic perspective. More recently, other important elements, such as those factors related to the host immune system, have been proposed as determinants of prognosis of CLM patients. In the present work, we review the current prognostic factors of CLM patients as well as the burgeoning shifting paradigm of prognostication that relies on the host immune system.
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相关论文
共 109 条
[1]   The Oncosurgery Approach to Managing Liver Metastases from Colorectal Cancer: A Multidisciplinary International Consensus [J].
Adam, Rene ;
De Gramont, Aimery ;
Figueras, Joan ;
Guthrie, Ashley ;
Kokudo, Norihiro ;
Kunstlinger, Francis ;
Loyer, Evelyne ;
Poston, Graeme ;
Rougier, Philippe ;
Rubbia-Brandt, Laura ;
Sobrero, Alberto ;
Tabernero, Josep ;
Teh, Catherine ;
Van Cutsem, Eric .
ONCOLOGIST, 2012, 17 (10) :1225-1239
[2]   Prognostic role of serum vascular endothelial growth factor, basic fibroblast growth factor and nitric oxide in patients with colorectal carcinoma [J].
Akbulut, H ;
Altuntas, F ;
Akbulut, KG ;
Ozturk, G ;
Cindoruk, M ;
Unal, E ;
Icli, F .
CYTOKINE, 2002, 20 (04) :184-190
[3]  
Aldrighetti Luca, 2005, Chir Ital, V57, P555
[4]   Hepatic resection for colorectal metastases - Analysis of prognostic factors [J].
Ambiru, S ;
Miyazaki, M ;
Isono, T ;
Ito, H ;
Nakagawa, K ;
Shimizu, H ;
Kusashio, K ;
Furuya, S ;
Nakajima, N .
DISEASES OF THE COLON & RECTUM, 1999, 42 (05) :632-639
[5]   Margin Status Remains an Important Determinant of Survival After Surgical Resection of Colorectal Liver Metastases in the Era of Modern Chemotherapy [J].
Andreou, Andreas ;
Aloia, Thomas A. ;
Brouquet, Antoine ;
Dickson, Paxton V. ;
Zimmitti, Giuseppe ;
Maru, Dipen M. ;
Kopetz, Scott ;
Loyer, Evelyne M. ;
Curley, Steven A. ;
Abdalla, Eddie K. ;
Vauthey, Jean-Nicolas .
ANNALS OF SURGERY, 2013, 257 (06) :1079-1088
[6]   The impact of margins on outcome after hepatic resection for colorectal metastasis [J].
Are, Chandrakanth ;
Gonen, Mithat ;
Zazzali, Kathleen ;
DeMatteo, Ronald P. ;
Jarnagin, William R. ;
Fong, Yuman ;
Blumgart, Leslie H. ;
D'Angelica, Miehael .
ANNALS OF SURGERY, 2007, 246 (02) :295-300
[7]   Anti-(epidermal growth factor) receptor monoclonal antibodies for the induction of antibody-dependent cell-mediated cytotoxicity against squamous cell carcinoma lines of the head and neck [J].
Bier, H ;
Hoffmann, T ;
Haas, I ;
van Lierop, A .
CANCER IMMUNOLOGY IMMUNOTHERAPY, 1998, 46 (03) :167-173
[8]   Rescue Chemotherapy Using Multidrug Chronomodulated Hepatic Arterial Infusion for Patients With Heavily Pretreated Metastatic Colorectal Cancer [J].
Bouchahda, Mohamed ;
Adam, Rene ;
Giacchetti, Sylvie ;
Castaing, Denis ;
Brezault-Bonnet, Catherine ;
Hauteville, Dominique ;
Innominato, Pasquale F. ;
Focan, Christian ;
Machover, David ;
Levi, Francis .
CANCER, 2009, 115 (21) :4990-4999
[9]   Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8+ T-cell axis [J].
Brackett, Craig M. ;
Kojouharov, Bojidar ;
Veith, Jean ;
Greene, Kellee F. ;
Burdelya, Lyudmila G. ;
Gollnick, Sandra O. ;
Abrams, Scott I. ;
Gudkov, Andrei V. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (07) :E874-E883
[10]   Liver Resection for Metastatic Colorectal Cancer in Patients with Concurrent Extrahepatic Disease: Results in 127 Patients Treated at a Single Center [J].
Carpizo, Darren R. ;
Are, Chandrakanth ;
Jarnagin, William ;
DeMatteo, Ronald ;
Fong, Yuman ;
Goenen, Mithat ;
Blumgart, Leslie ;
D'Angelica, Michael .
ANNALS OF SURGICAL ONCOLOGY, 2009, 16 (08) :2138-2146
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