Efficient Copper-Catalyzed Coupling of 2-Haloacetanilides with Phosphine Oxides and Phosphites under Mild Conditions

被引：24

作者：

Jiang, Deshou ^{[1
]}

Jiang, Qun ^{[2
]}

Fu, Hua ^{[1
]}

Jiang, Yuyang ^{[1
,2
]}

Zhao, Yufen ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Beijing 100084, Peoples R China

[2] Tsinghua Univ, Grad Sch Shenzhen, Key Lab Chem Biol Guangdong Prov, Shenzhen 518057, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2008年 / 21期

基金：

中国国家自然科学基金;

关键词：

Ullmann reaction; P-arylation; ortho effect; copper catalysis; N; N-ligand;

D O I：

10.1055/s-0028-1083155

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed a highly efficient method for the copper-catalyzed coupling of 2-haloacetanilides with phosphine oxides and phosphites in the presence of a catalytic amount of copper(I) iodide and N-methylpyrrolidine-2-carboxamide tinder mild conditions (45-55 degrees C); the P-arylation products were synthesized in good to excellent yields in short times using 2-bromotrifluoroacetanilides and 2-iodotrifluoroacetanilides as the starting materials. This represents the lowest reaction temperatures for copper-catalyzed P-arylation thus far.

引用

页码：3473 / 3477

页数：5

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