Relationship between chemical structure and antileishmanial effect of sinefungine analogues.

被引：6
作者：
Blanchard, P [1 ]
ElKortbi, MS [1 ]
Fourrey, JL [1 ]
Lawrence, F [1 ]
RobertGero, M [1 ]
机构：
[1] CNRS,INST CHIM SUBST NAT,F-91198 GIF SUR YVETTE,FRANCE
来源：
NUCLEOSIDES & NUCLEOTIDES | 1996年 / 15卷 / 06期
关键词：
D O I：
10.1080/07328319608007381
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis of various analogues of sinefungin (1), having structures 2-5, has been developed by means of an original approach which uses radical chemistry. The study of their biological activities revealed that for the antileishmanial effect of sinefungin, the presence of the amino group at C-6' in the (S)-configuration and the presence of the carboxyl group at C-9' are necessary.
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页码：1121 / 1135
页数：15
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