MALAT-1 interacts with hnRNP C in cell cycle regulation

被引：128

作者：

Yang, Feng

Yi, Fan

Han, Xiaorui

Du, Quan ^{[1
]}

Liang, Zicai

机构：

[1] Peking Univ, Sch Pharmaceut Sci, Inst Mol Med, Beijing 100871, Peoples R China

来源：

FEBS LETTERS | 2013年 / 587卷 / 19期

基金：

北京市自然科学基金;

关键词：

MALAT-1; Long non-coding RNA; Cell cycle; hnRNP C; LONG NONCODING RNA; GENE-EXPRESSION; MOUSE DEVELOPMENT; LUNG-CANCER; METASTASIS; COMPLEXES; TRANSLATION; COMPONENTS; GENOME; C1/C2;

D O I：

10.1016/j.febslet.2013.07.048

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As a conserved non-coding RNA gene, transcripts of MALAT-1 localize predominately in the nucleus. However in G2/M cell cycle phase, MALAT-1 transcripts were surprisingly found to translocate from the nucleus into the cytoplasm. Investigation also found that in this process MALAT-1 interacts with an abundant nuclear factor, hnRNP C protein. Using a loss-of-function assay, we found that downregulation of MALAT-1 expression compromised the cytoplasmic translocation of hnRNP C in the G2/M phase and resulted in G2/M arrest. In addition to characterize the physiological interaction between MALAT-1 and hnRNP C, our study also highlights the role of MALAT-1 in cell cycle regulation. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：3175 / 3181

页数：7

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