A Direct Phosphine-Mediated Synthesis of Pyrroles from Acid Chlorides and α,β-Unsaturated Imines

被引：78

作者：

Lu, Yingdong ^{[1
]}

Arndtsen, Bruce A. ^{[1
]}

机构：

[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 06期

关键词：

HIGHLY SUBSTITUTED PYRROLES; ONE-POT; REGIOSELECTIVE SYNTHESIS; PROPARGYLIC ALCOHOLS; BIOLOGICAL-ACTIVITY; LAMELLARIN-O; LUKIANOL-A; CONDENSATION; ALKALOIDS; ALKYNES;

D O I：

10.1021/ol900185n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-step method to assemble pyrroles from alpha,beta-unsaturated imines and acid chlorides has been developed. This reaction is mediated by triphenylphosphine, which eliminates phosphine oxide to allow cyclization. This reaction has been employed to access a diverse range of pyrroles via modulation of the two building blocks and applied as well to the synthesis of lukianol A.

引用

收藏

页码：1369 / 1372

页数：4

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