A Direct Phosphine-Mediated Synthesis of Pyrroles from Acid Chlorides and α,β-Unsaturated Imines

被引：78
作者：
Lu, Yingdong [1 ]
Arndtsen, Bruce A. [1 ]
机构：
[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 06期
关键词：
HIGHLY SUBSTITUTED PYRROLES; ONE-POT; REGIOSELECTIVE SYNTHESIS; PROPARGYLIC ALCOHOLS; BIOLOGICAL-ACTIVITY; LAMELLARIN-O; LUKIANOL-A; CONDENSATION; ALKALOIDS; ALKYNES;
D O I：
10.1021/ol900185n
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-step method to assemble pyrroles from alpha,beta-unsaturated imines and acid chlorides has been developed. This reaction is mediated by triphenylphosphine, which eliminates phosphine oxide to allow cyclization. This reaction has been employed to access a diverse range of pyrroles via modulation of the two building blocks and applied as well to the synthesis of lukianol A.
引用
收藏
页码：1369 / 1372
页数：4
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