The Hallmarks of Cancer and the Radiation Oncologist: Updating the 5Rs of Radiobiology

被引：62

作者：

Good, J. S. ^{[1
]}

Harrington, K. J. ^{[1
,2
]}

机构：

[1] Royal Marsden Hosp, Head & Neck Unit, London SW3 6JJ, England

[2] Inst Canc Res, Targeted Therapy Lab, London SW3 6JB, England

来源：

CLINICAL ONCOLOGY | 2013年 / 25卷 / 10期

关键词：

Radiobiology; radiosensitivity; redistribution; reoxygenation; repair; repopulation; ENDOTHELIAL GROWTH-FACTOR; IONIZING-RADIATION; DNA-REPAIR; TGF-BETA; CELLS; RADIOTHERAPY; INHIBITION; TELOMERASE; METABOLISM; IRRADIATION;

D O I：

10.1016/j.clon.2013.06.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A comprehensive, mechanistic understanding of radiobiological phenomena that can be integrated within the broader context of cancer biology offers the prospect of transforming clinical practice in radiation oncology. In this review, we revisit the six established biological hallmarks of cancer and examine how they have provided insights into novel therapeutic strategies. In addition, we discuss the potential of two emerging hallmarks to continue to expand our understanding beyond the narrow confines of the traditional 5Rs of radiobiology. (C) 2013 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.

引用

页码：569 / 577

页数：9