Dietary Marine-Derived Tocopherol has a Higher Biological Availability in Mice Relative to Alpha-Tocopherol

被引：23

作者：

Gotoh, Naohiro ^{[1
]}

Watanabe, Hiroyuki ^{[2
]}

Oka, Tomiko ^{[1
]}

Mashimo, Daisuke ^{[1
]}

Noguchi, Noriko ^{[3
]}

Hata, Kazuhiko ^{[4
]}

Wada, Shun ^{[1
]}

机构：

[1] Tokyo Univ Marine Sci & Technol, Dept Food Sci & Technol, Minato Ku, Tokyo 1088477, Japan

[2] Kochi Womens Univ, Dept Hlth Sci, Kochi 7808515, Japan

[3] Univ Tokyo, Adv Sci & Technol Res Ctr, Lab Syst Biol & Med, Tokyo 1538904, Japan

[4] Nippon Suisan Kaisha Ltd, Tokyo 1920906, Japan

来源：

LIPIDS | 2009年 / 44卷 / 02期

关键词：

alpha-Tocomonoenol; Liver; Marine-derived tocopherol; Mouse; Vitamin E relative biologic availability; PROTEIN-NULL MICE; LIVER-STORAGE BIOASSAY; VITAMIN-E; DIALURIC ACID; TOCOMONOENOL; DISCRIMINATION; BIOKINETICS; INVIVO; PLASMA; TISSUE;

D O I：

10.1007/s11745-008-3257-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The biologic availability of two kinds of tocomonoenols, marine-derived tocopherol (MDT) and alpha-tocomonoenol, was investigated in ICR mice. Vitamin E-deficient ICR mice were fed MDT and alpha-tocomonoenol together with alpha-tocopherol, beta-tocopherol, gamma-tocopherol, and delta-tocopherol, and storage in liver, spleen, lung, and brain was quantified using reverse-phase high-performance liquid chromatography. The vitamin E relative biologic availability (VE-RBA) in liver was 100 for alpha-tocopherol, 26 +/- A 3 for beta-tocopherol, 4 +/- A 2 for gamma-tocopherol, not detected for delta-tocopherol, 49 +/- A 6 for MDT, and 30 +/- A 7 for alpha-tocomonoenol. The VE-RBA in brain was 100 for alpha-tocopherol, 5 +/- A 2 for beta-tocopherol, not detected for gamma-tocopherol and delta-tocopherol, 8 +/- A 1 for MDT, and 4 +/- A 1 for alpha-tocomonoenol. Tocopherols and tocomonoenols did not accumulate in the spleen or lung. MDT and alpha-tocomonoenol had high VE-RBA values. The VE-RBA value for MDT was much higher than that for beta-tocopherol.

引用

页码：133 / 143

页数：11

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