Expanding the synthesis of new trans-sulfonamide platinum complexes: Cytotoxicity, SAR, fluorescent cell assays and stability studies

被引：16

作者：

del Solar, Virginia ^{[1
]}

Quinones-Lombrana, Adolfo ^{[2
]}

Cabrera, Silvia ^{[1
]}

Padron, Jose M. ^{[3
]}

Rios-Luci, Carla ^{[3
]}

Alvarez-Valdes, Amparo ^{[1
]}

Navarro-Ranninger, Carmen ^{[1
]}

Aleman, Jose ^{[4
]}

机构：

[1] Univ Autonoma Madrid, Fac Ciencias, Dept Quim Inorgan Modulo 7, E-28049 Madrid, Spain

[2] SUNY Buffalo, Dept Pharmaceut Sci, Buffalo, NY 14214 USA

[3] Univ La Laguna, Inst Univ Bioorgan Antonio Gonzalez, San Cristobal la Laguna 38206, Tenerife, Spain

[4] Univ Autonoma Madrid, Fac Ciencias, Dept Quim Organ Modulo 1, E-28049 Madrid, Spain

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2013年 / 127卷

关键词：

Trans-platinum complexes; Sulfonamides; SAR; Fluorescent assays; METALLODRUG-PROTEIN INTERACTIONS; MASS-SPECTROMETRY; PT(II) COMPLEXES; ANTICANCER; REACTIVITY; CISPLATIN; DRUGS; SATRAPLATIN; DERIVATIVES; MECHANISMS;

D O I：

10.1016/j.jinorgbio.2013.01.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this manuscript, we describe the synthesis of new trans-N-sulfonamide platinum complexes and their antiproliferative activity (GI(50), mu M) in human solid tumors cells. The structure activity relationships (SAR), with different new synthesized complexes by variation in ligand, halogen and also in the stereochemistry of the ligand, has been studied. Solubility and stability studies have also been carried out as well as fluorescent cell assays in order to clarify the final target in the tumor cells. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：128 / 140

页数：13

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