Lung-brain interaction in the mechanically ventilated patient

被引：16

作者：

Lopez-Aguilar, J. ^{[1
,2
,3
,4
]}

Fernandez-Gonzalo, M. S. ^{[1
,5
]}

Turon, M. ^{[1
,5
]}

Quilez, M. E. ^{[3
]}

Gomez-Simon, V. ^{[1
,2
,4
]}

Jodar, M. M. ^{[5
,6
]}

Blanch, L. ^{[1
,2
,3
,4
]}

机构：

[1] Corp Sanitaria Parc Tauli, Fundacio Parc Tauli, Barcelona, Spain

[2] Univ Autonoma Barcelona, Inst Univ Parc Tauli, E-08193 Barcelona, Spain

[3] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Resp, Madrid, Spain

[4] Corp Sanitaria Parc Tauli, Hosp Sabadell, Serv Med Intens, Barcelona, Spain

[5] Univ Autonoma Barcelona, Dept Psicol Clin & Salut, E-08193 Barcelona, Spain

[6] Corp Sanitaria Parc Tauli, Hosp Sabadell, Serv Neurol, Barcelona, Spain

来源：

MEDICINA INTENSIVA | 2013年 / 37卷 / 07期

关键词：

Acute lung injury; Acute respiratory distress syndrome; Mechanical ventilation; Neuropsychological and cognitive impairment; Lung-brain interaction; Confusional syndrome; Delirium; Central nervous system; Intensive care unit; RESPIRATORY-DISTRESS-SYNDROME; INTENSIVE-CARE-UNIT; QUALITY-OF-LIFE; CONFUSION ASSESSMENT METHOD; TERM COGNITIVE IMPAIRMENT; CRITICAL ILLNESS; CONTROLLED-TRIAL; CRITICALLY-ILL; PORCINE MODEL; AIR HUNGER;

D O I：

10.1016/j.medin.2012.10.005

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Patients with acute lung injury or acute respiratory distress syndrome (ARDS) admitted to the ICU present neuropsychological alterations, which in most cases extend beyond the acute phase and have an important adverse effect upon quality of life. The aim of this review is to deepen in the analysis of the complex interaction between lung and brain in critically ill patients subjected to mechanical ventilation. This update first describes the neuropsychological alterations occurring both during the acute phase of ICU stay and at discharge, followed by an analysis of lung-brain interactions during mechanical ventilation, and finally explores the etiology and mechanisms leading to the neurological disorders observed in these patients. The management of critical patients requires an integral approach focused on minimizing the deleterious effects over the short, middle or long term. (C) 2012 Elsevier Espana, S.L. and SEMICYUC. All rights reserved.

引用

页码：485 / 492

页数：8

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