Preventive Effects of LBP on Cisplatin-Induced Nephrotoxicity in 293 Cell

被引：0

作者：

Leng Hong-tao

Gao Li-ping ^{[1
]}

机构：

[1] Beijing Union Univ, Biol Act Subst, Beijing, Peoples R China

来源：

2011 INTERNATIONAL CONFERENCE ON ENVIRONMENTAL SYSTEMS SCIENCE AND ENGINEERING (ICESSE 2011), VOL 3 | 2011年

关键词：

Cisplatin; LBP; nephrotoxicity; HEK293; oxidative stress;

D O I：

暂无

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Objective To investigate the protective effects of Lycium barbarum polysaccharides (LBP) on cisplatin(CDDP)-induced nephrotoxicity in human embryo kidney 293 cells and its possible mechanism.Methods Through HEK293 cells grouping,the effect of LBP,CDDP and LBP on CDDP-induced cytotoxicity was observed by MTT assay.Lipid peroxidation and GSH were determined.Results Cisplatin to MDA concentrations were significantly increased, decreased cell viability, apoptosis rate increased. After the role of LBP in a certain range, MDA concentration decreased significantly increased cell viability, apoptosis rate. Conclusion LBP can alleviate CDDP-induced cytotoxicity in 293 cells. Antioxidation and scavenging of free radicals underlies the mechanism.

引用

页码：562 / 567

页数：6

共 10 条

[1] Vitamin C attenuates cisplatin-induced alterations in renal brush border membrane enzymes and phosphate transport [J].