Pathogenesis and prevention of acute and chronic lung disease in newborn infants

被引:0
作者
Davis, JM [1 ]
机构
[1] SUNY Stony Brook, Winthrop Univ Hosp, Sch Med, Dept Pediat, Mineola, NY 11501 USA
来源
ETIOLOGY AND TREATMENT OF ACUTE LUNG INJURY: FROM BENCH TO BEDSIDE | 2001年 / 336卷
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中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
With the introduction of new treatment modalities, more critically ill infants are surviving the neonatal period and developing acute and chronic lung injury such as Bronchopulmonary Dysplasia (BPD). The development of BPD is associated with significant morbidity and mortality. BPD is hypothesized to begin as acute inflammatory changes in the lung secondary to a variety of prenatal/postnatal insults including toxic reactive oxygen species (ROS), which then evolve into chronic lung disease. The premature neonate may be particularly vulnerable to oxidant injury, since endogenous antioxidant enzyme activity may be deficient at birth. A logical strategy to prevent oxidant-induced lung injury is supplementation with antioxidant enzymes (AOE). This chapter will focus on the basic science and clinical studies involved in the development of antioxidant strategies to prevent BPD in newborns and Acute Respiratory Distress Syndrome (ARDS) -related injuries in adults.
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页码:86 / 92
页数:7
相关论文
共 27 条
[1]  
Albert George P., 1998, Pediatric Research, V43, p272A
[2]  
[Anonymous], EFFECTIVE CARE NEWBO
[3]   INCREASED ACTIVITY OF INTERLEUKIN-6 BUT NOT TUMOR-NECROSIS-FACTOR-ALPHA IN LUNG LAVAGE OF PREMATURE-INFANTS IS ASSOCIATED WITH THE DEVELOPMENT OF BRONCHOPULMONARY DYSPLASIA [J].
BAGCHI, A ;
VISCARDI, RM ;
TACIAK, V ;
ENSOR, JE ;
MCCREA, KA ;
HASDAY, JD .
PEDIATRIC RESEARCH, 1994, 36 (02) :244-252
[4]  
Biswas Saumitra, 1998, Pediatric Research, V43, p208A
[5]   NEURODEVELOPMENTAL OUTCOME IN INFANTS WITH BRONCHOPULMONARY DYSPLASIA [J].
BREGMAN, J ;
FARRELL, EE .
CLINICS IN PERINATOLOGY, 1992, 19 (03) :673-694
[6]   MICE LACKING EXTRACELLULAR-SUPEROXIDE DISMUTASE ARE MORE SENSITIVE TO HYPEROXIA [J].
CARLSSON, LM ;
JONSSON, J ;
EDLUND, T ;
MARKLUND, SL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (14) :6264-6268
[7]  
DAS S, 1998, AM J PHYSIOL, P274
[8]   Safety and pharmacokinetics of multiple doses of recombinant human CuZn superoxide dismutase administered intratracheally to premature neonates with respiratory distress syndrome [J].
Davis, JM ;
Rosenfeld, WN ;
Richter, SE ;
Parad, R ;
Gewolb, IH ;
Spitzer, AR ;
Carlo, WA ;
Couser, RJ ;
Price, A ;
Flaster, E ;
Kassem, N ;
Edwards, L ;
Tierney, J ;
Horowitz, S .
PEDIATRICS, 1997, 100 (01) :24-30
[9]   PROPHYLACTIC EFFECTS OF RECOMBINANT HUMAN SUPEROXIDE-DISMUTASE IN NEONATAL LUNG INJURY [J].
DAVIS, JM ;
ROSENFELD, WN ;
SANDERS, RJ ;
GONENNE, A .
JOURNAL OF APPLIED PHYSIOLOGY, 1993, 74 (05) :2234-2241
[10]  
DAVIS JM, 1999, NEONATOLOGY, P453