N,N′-substituted 1,2,5 thiadiazolidine 1,1-dioxides:: Synthesis, selected chemical and spectral proprieties and antimicrobial evaluation

被引：14

作者：

Bendjeddou, A ^{[1
]}

Djeribi, R ^{[1
]}

Regainia, Z ^{[1
]}

Aouf, NE ^{[1
]}

机构：

[1] Univ Annaba, Dept Chim, Fac Sci, Grp Chim Bioorgan,Lab Chim Organ Appliquee, Annaba, Algeria

来源：

MOLECULES | 2005年 / 10卷 / 11期

关键词：

amino acids; cyclic sulfamides; cyclization; Mitsunobu reaction; propionylation; constrained peptides;

D O I：

10.3390/10111387

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The sulfamide functional group is increasingly relevant in both medicinal and bioorganic chemistry. We report here practical access to a series of N2,N5-substituted five-membered cyclosulfamides. The five-membered heterocyclic motif was prepared starting from proteogenic amino acids and chlorosulfonyl isocyanate via the Mitsunobu reaction. Selected chemical and spectral proprieties and the antimicrobial evaluation of these compounds are detailed.

引用

页码：1387 / 1398

页数：12

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