Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010

被引：24

作者：

Colafigli, M. ^{[1
]}

Torti, C. ^{[2
]}

Trecarichi, E. M. ^{[1
]}

Albini, L. ^{[2
]}

Rosi, A. ^{[3
]}

Micheli, V. ^{[4
]}

Manca, N. ^{[5
]}

Penco, G. ^{[6
]}

Bruzzone, B. ^{[7
]}

Punzi, G. ^{[8
]}

Corsi, P. ^{[9
]}

Parruti, G. ^{[10
]}

Bagnarelli, P. ^{[11
]}

Monno, L. ^{[8
]}

Gonnelli, A. ^{[12
]}

Cauda, R. ^{[1
]}

Di Giambenedetto, S. ^{[1
]}

机构：

[1] Univ Cattolica Sacro Cuore, Inst Clin Infect Dis, I-00168 Rome, Italy

[2] Univ Brescia, Inst Infect & Trop Dis, Brescia, Italy

[3] Univ Siena, Dept Biotechnol, I-53100 Siena, Italy

[4] L Sacco Hosp Vialba, Microbiol Lab, Milan, Italy

[5] Univ Brescia, Dept Virol, Brescia, Italy

[6] EO Osped Galliera, Dept Infect Dis, Genoa, Italy

[7] San Martino Hosp, Lab Hygene, Genoa, Italy

[8] Univ Bari, Bari, Italy

[9] Careggi Hosp, Div Infect Dis, Florence, Italy

[10] Hosp Pescara, Pescara, Italy

[11] Univ Politecn Marche, Dept Biomed Sci & Publ Hlth, Virol Lab, Ancona, Italy

[12] Policlin Santa Maria Scotte, Infect Dis & Liver Unit, Siena, Italy

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2012年 / 18卷 / 08期

关键词：

Antiretroviral therapy; chronic HIV infection; recent HIV infection; resistance epidemiology; transmitted resistance; INITIAL TREATMENT; NAIVE; LOPINAVIR/RITONAVIR; PREVALENCE; MUTATIONS; EFFICACY; SAFETY;

D O I：

10.1111/j.1469-0691.2012.03847.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Clin Microbiol Infect Abstract Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naive HIV-1-infected patients, with a genotypic resistance test (GRT) performed =6 months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR.

引用

页码：E299 / E304

页数：6

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