Exodus-1 (CCL20): evidence for the participation of this chemokine in spontaneous labor at term, preterm labor, and intrauterine infection

被引：56

作者：

Hamill, Neil ^{[1
,2
,3
]}

Romero, Roberto ^{[1
,2
,4
]}

Gotsch, Francesca ^{[1
,2
]}

Kusanovic, Juan Pedro ^{[1
,2
,3
]}

Edwin, Sam ^{[1
,2
]}

Erez, Offer ^{[1
,2
]}

Than, Nandor Gabor ^{[1
,2
]}

Mittal, Pooja ^{[1
,2
,3
]}

Espinoza, Jimmy ^{[1
,2
,3
]}

Friel, Lara A. ^{[1
,2
,3
]}

Vaisbuch, Edi ^{[1
,2
]}

Mazaki-Tovi, Shali ^{[1
,2
,3
]}

Hassan, Sonia S. ^{[1
,2
,3
]}

机构：

[1] Wayne State Univ, Hutzel Womens Hosp, Perinatol Res Branch, NICHD NIH DHHS, Detroit, MI 48201 USA

[2] DHHS, NIH, NICHD, Perinatol Res Branch, Bethesda, MD USA

[3] Wayne State Univ, Hutzel Womens Hosp, Dept Obstet & Gynecol, Detroit, MI 48201 USA

[4] Wayne State Univ, Ctr Mol Med & Genet, Detroit, MI 48201 USA

来源：

JOURNAL OF PERINATAL MEDICINE | 2008年 / 36卷 / 03期

关键词：

amniotic fluid; cytokine; inflammation; LARC; macrophage inflammatory protein 3 alpha; parturition; pregnancy;

D O I：

10.1515/JPM.2008.034

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Aim: CCL20, also known as MIP-3 alpha, is a chemokine that participates in chemotaxis of immature dendritic cells, effector/memory T-cells, and B-lymphocytes. The objectives of this study were to determine whether CCL20 can be detected in amniotic fluid (AF) and if AF concentration of this chemokine changes with advancing gestational age, parturition (term and preterm), and intraamniotic infection/inflammation (IAI). Methods: A cross-sectional study was conducted including the following groups: (1) mid-trimester of pregnancy (n=65); (2) term not in labor (TNL; n=22); (3) term in labor (TI L; n = 47); (4) spontaneous preterm labor (PTL) who delivered at term (n = 57); (5) spontaneous PTL without IAI who delivered preterm (n=71); and (6) spontaneous PTL with IAI (n=38). AF CCL20 concentrations were determined using ELISA. Results: (1) The median AF CCL20 concentration in TNL was higher than that of mid-trimester patients; (2) Women in spontaneous labor at term had a higher median AF concentration of CCL20 than patients at term not in labor; (3) Patients with spontaneous PTL and IAI had a significantly higher median AF concentration of CCL20 than those without IAl who delivered preterm and those who delivered at term. Moreover, women with spontaneous PTL without IAl who delivered preterm had a significantly higher median AF concentration than those with PTL who subsequently delivered at term. Conclusions: (1) CCL20 is a physiologic constituent of AF and its concentration increases as term approaches; (2) spontaneous labor (term and preterm) in the absonce of IAl is associated with increased bioavailability of AF CCL20 suggesting that an increase in CCL20 is part of the common pathway of human parturition; (3) patients with IAl had dramatic elevations in the AF CCL20 concentrations suggesting that this chemokine participates in the host response to infection or other stimuli associated with intra-amniotic infection.

引用

页码：217 / 227

页数：11

共 141 条

[1] Host defense proteins in vernix caseosa and amniotic fluid [J].