Use of Adipose-Derived Stem Cells to Support Topical Skin Adhesive for Wound Closure: A Preliminary Report from Animal In Vivo Study

被引：9

作者：

Nowacki, Maciej ^{[1
]}

Pietkun, Katarzyna ^{[2
,3
]}

Jundzill, Arkadiusz ^{[4
,5
]}

Kloskowski, Tomasz ^{[5
]}

Grzanka, Dariusz ^{[6
]}

Skopinska-Wisniewska, Joanna ^{[7
]}

Scibior, Kinga ^{[6
]}

Gagat, Maciej ^{[8
]}

Pokrywczynska, Marta ^{[5
]}

Grzanka, Alina ^{[8
]}

Zegarski, Wojciech ^{[1
]}

Czajkowski, Rafal ^{[6
]}

Drewa, Tomasz ^{[5
]}

Zegarska, Barbara ^{[2
]}

机构：

[1] Nicolaus Copernicus Univ Torun, Prof Franciszek Lukaszczyk Mem Hosp Bydgoszcz, Ludwik Rydygier Coll Med Bydgoszcz, Chair & Dept Surg Oncol,Oncol Ctr, Ul Romanowskiej 2, PL-85796 Bydgoszcz, Poland

[2] Nicolaus Copernicus Univ Torun, Ludwik Rydygier Coll Med Bydgoszcz, Chair Cosmetol & Aesthet Dermatol, Ul Jagiellonska 15, PL-85067 Bydgoszcz, Poland

[3] Nicolaus Copernicus Univ Torun, Ludwik Rydygier Coll Med Bydgoszcz, Chair & Dept Rehabil, Ul M Curie Sklodowskiej 9, PL-85094 Bydgoszcz, Poland

[4] Nicolaus Copernicus Univ Torun, Ludwik Rydygier Coll Med Bydgoszcz, Dept Plast Reconstruct & Aesthet Surg, Ul M Curie Sklodowskiej 9, PL-85094 Bydgoszcz, Poland

[5] Nicolaus Copernicus Univ Torun, Ludwik Rydygier Coll Med Bydgoszcz, Dept Regenerat Med, Chair Urol, Ul M Curie Sklodowskiej 9, PL-85094 Bydgoszcz, Poland

[6] Nicolaus Copernicus Univ Torun, Ludwik Rydygier Coll Med Bydgoszcz, Dept & Clin Dermatol Sexually Transmitted Dis & I, Ul M Curie Sklodowskiej 9, PL-85094 Bydgoszcz, Poland

[7] Nicolaus Copernicus Univ Torun, Fac Chem, Dept Chem Biomat & Cosmet, Gagarina 7, PL-87100 Torun, Poland

[8] Nicolaus Copernicus Univ Torun, Ludwik Rydygier Coll Med Bydgoszcz, Dept Histol & Embryol, Ul Karlowicza 24, PL-85092 Bydgoszcz, Poland

来源：

BIOMED RESEARCH INTERNATIONAL | 2016年 / 2016卷

关键词：

TISSUE; SUTURES; DEVICE;

D O I：

10.1155/2016/2505601

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The aim of this study was to determine the local and systemic effects of adipose-derived stem cells (ADSCs) as a component of topical skin adhesive in an animal artificial wound closure model. In presented study the cosmetic effects, histological analysis, mechanical properties, and cell migration have been assessed to evaluate the usefulness of ADSCs as supporting factor for octyl blend cyanoacrylate adhesive. The total of 40 rats were used and divided into six groups. In the Study Group, ADSCs were administered by multipoint injection of the six surrounding intrawound areas with additional freely leaving procedure of the cells between the skin flaps just before applying adhesive to close the wound. Five control groups without using ADSCs, utilizing different types of standard wound closure, were created in order to check efficiency of experimental stem cell therapy. In our study, we proved that ADSCs could be used effectively also as a supportive tool in topical skin adhesive for wound closure. However we did not achieve any spectacular differences related to such aspects as better mechanical properties or special biological breakthroughs in wound healing properties. The use of stem cells, especially ADSCs for wound closure can provide an inspiring development in plastic and dermatologic surgery.

引用

页数：10

共 36 条

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