miRNA profiling for biomarker discovery in multiple sclerosis: From microarray to deep sequencing

被引：67

作者：

Guerau-de-Arellano, Mireia ^{[1
,2
]}

Alder, Hansjuerg ^{[3
]}

Ozer, Hatice Gulcin ^{[4
]}

Lovett-Racke, Amy ^{[3
]}

Racke, Michael K. ^{[1
]}

机构：

[1] Ohio State Univ, Med Ctr, Dept Neurol, Columbus, OH 43210 USA

[2] Ohio State Univ, Dept Neurosci, Columbus, OH 43210 USA

[3] Ohio State Univ, Med Ctr, Mol Virol Immunol & Med Genet Dept, Columbus, OH 43210 USA

[4] Ohio State Univ, Med Ctr, Ctr Comprehens Canc, Columbus, OH 43210 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2012年 / 248卷 / 1-2期

关键词：

miRNA; Profiling; Biomarker; Multiple sclerosis; Neuroimmunology; Autoimmunity; MYELIN BASIC-PROTEIN; MICRORNA GENES; C-ELEGANS; RNA-INTERFERENCE; T-CELLS; EXPRESSION; DIFFERENTIATION; AUTOIMMUNITY; BIOGENESIS; TARGETS;

D O I：

10.1016/j.jneuroim.2011.10.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level. miRNAs are highly expressed in cells of the immune and nervous system, attesting to their importance in Neuroimmunology. Besides their involvement in modulation of physiological and pathological processes, miRNAs hold high promise as disease biomarkers, therapeutic agents and/or drug targets. Several studies have recently explored the involvement of miRNAs in Multiple Sclerosis (MS) using a variety of miRNA profiling techniques. In this review, we discuss basic miRNA biology and nomenclature, the techniques available for miRNA profiling research and recent miRNA profiling studies in Multiple Sclerosis. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：32 / 39

页数：8

共 64 条

[51] Quantification of self-recognition in multiple sclerosis by single-cell analysis of cytokine production [J].

Pelfrey, CM ;

Rudick, RA ;

Cotleur, AC ;

Lee, JC ;

Tary-Lehmann, M ;

Lehmann, PV .

JOURNAL OF IMMUNOLOGY, 2000, 165 (03) :1641-1651

[52] E2F1-regulated microRNAs impair TGFβ-dependent cell-cycle arrest and apoptosis in gastric cancer [J].

Petrocca, Fabio ;

Visone, Rosa ;

Onelli, Mariadele Rapazzotti ;

Shah, Manisha H. ;

Nicoloso, Milena S. ;

de Martino, Ivana ;

Iliopoulos, Dimitrios ;

Pilozzi, Emanuela ;

Liu, Chang-Gong ;

Negrini, Massimo ;

Cavazzini, Luigi ;

Volinia, Stefano ;

Alder, Hansjuerg ;

Ruco, Luigi P. ;

Baldassarre, Gustavo ;

Croce, Carlo M. ;

Vecchione, Andrea .

CANCER CELL, 2008, 13 (03) :272-286

[53] MicroRNA-373 induces expression of genes with complementary promoter sequences [J].

Place, Robert F. ;

Li, Long-Cheng ;

Pookot, Deepa ;

Noonan, Emily J. ;

Dahiya, Rajvir .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (05) :1608-1613

[54] The development and impact of 454 sequencing [J].

Rothberg, Jonathan M. ;

Leamon, John H. .

NATURE BIOTECHNOLOGY, 2008, 26 (10) :1117-1124

[55] Advanced sequencing technologies: Methods and goals [J].

Shendure, J ;

Mitra, RD ;

Varma, C ;

Church, GM .

NATURE REVIEWS GENETICS, 2004, 5 (05) :335-344

[56]

Tili Esmerina, 2007, Future Oncol, V3, P521, DOI 10.2217/14796694.3.5.521

[57] POSTTRANSCRIPTIONAL REGULATION OF THE HETEROCHRONIC GENE LIN-14 BY LIN-4 MEDIATES TEMPORAL PATTERN-FORMATION IN C-ELEGANS [J].

WIGHTMAN, B ;

HA, I ;

RUVKUN, G .

CELL, 1993, 75 (05) :855-862

[58] Post-transcriptional generation of miRNA variants by multiple nucleotidyl transferases contributes to miRNA transcriptome complexity [J].

Wyman, Stacia K. ;

Knouf, Emily C. ;

Parkin, Rachael K. ;

Fritz, Brian R. ;

Lin, Daniel W. ;

Dennis, Lucas M. ;

Krouse, Michael A. ;

Webster, Philippa J. ;

Tewari, Muneesh .

GENOME RESEARCH, 2011, 21 (09) :1450-1461

[59] Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes [J].

Xiao, Changchun ;

Srinivasan, Lakshmi ;

Calado, Dinis Pedro ;

Patterson, Heide Christine ;

Zhang, Baochun ;

Wang, Jing ;

Henderson, Joel M. ;

Kutok, Jeffrey L. ;

Rajewsky, Klaus .

NATURE IMMUNOLOGY, 2008, 9 (04) :405-414

[60] Widespread regulatory activity of vertebrate microRNA* species [J].

Yang, Jr-Shiuan ;

Phillips, Michael D. ;

Betel, Doron ;

Mu, Ping ;

Ventura, Andrea ;

Siepel, Adam C. ;

Chen, Kevin C. ;

Lai, Eric C. .

RNA, 2011, 17 (02) :312-326

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