miRNA profiling for biomarker discovery in multiple sclerosis: From microarray to deep sequencing

被引：67

作者：

Guerau-de-Arellano, Mireia ^{[1
,2
]}

Alder, Hansjuerg ^{[3
]}

Ozer, Hatice Gulcin ^{[4
]}

Lovett-Racke, Amy ^{[3
]}

Racke, Michael K. ^{[1
]}

机构：

[1] Ohio State Univ, Med Ctr, Dept Neurol, Columbus, OH 43210 USA

[2] Ohio State Univ, Dept Neurosci, Columbus, OH 43210 USA

[3] Ohio State Univ, Med Ctr, Mol Virol Immunol & Med Genet Dept, Columbus, OH 43210 USA

[4] Ohio State Univ, Med Ctr, Ctr Comprehens Canc, Columbus, OH 43210 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2012年 / 248卷 / 1-2期

关键词：

miRNA; Profiling; Biomarker; Multiple sclerosis; Neuroimmunology; Autoimmunity; MYELIN BASIC-PROTEIN; MICRORNA GENES; C-ELEGANS; RNA-INTERFERENCE; T-CELLS; EXPRESSION; DIFFERENTIATION; AUTOIMMUNITY; BIOGENESIS; TARGETS;

D O I：

10.1016/j.jneuroim.2011.10.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level. miRNAs are highly expressed in cells of the immune and nervous system, attesting to their importance in Neuroimmunology. Besides their involvement in modulation of physiological and pathological processes, miRNAs hold high promise as disease biomarkers, therapeutic agents and/or drug targets. Several studies have recently explored the involvement of miRNAs in Multiple Sclerosis (MS) using a variety of miRNA profiling techniques. In this review, we discuss basic miRNA biology and nomenclature, the techniques available for miRNA profiling research and recent miRNA profiling studies in Multiple Sclerosis. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：32 / 39

页数：8

共 64 条

[21] An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells [J].

Hammond, SM ;

Bernstein, E ;

Beach, D ;

Hannon, GJ .

NATURE, 2000, 404 (6775) :293-296

[22] A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA [J].

Hutvágner, G ;

McLachlan, J ;

Pasquinelli, AE ;

Bálint, É ;

Tuschl, T ;

Zamore, PD .

SCIENCE, 2001, 293 (5531) :834-838

[23] Zcchc11-dependent uridylation of microRNA directs cytokine expression [J].

Jones, Matthew R. ;

Quinton, Lee J. ;

Blahna, Matthew T. ;

Neilson, Joel R. ;

Fu, Suneng ;

Ivanov, Alexander R. ;

Wolf, Dieter A. ;

Mizgerd, Joseph P. .

NATURE CELL BIOLOGY, 2009, 11 (09) :1157-U258

[24] MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47 [J].

Junker, Andreas ;

Krumbholz, Markus ;

Eisele, Sylvia ;

Mohan, Hema ;

Augstein, Florian ;

Bittner, Robert ;

Lassmann, Hans ;

Wekerle, Hartmut ;

Hohlfeld, Reinhard ;

Meinl, Edgar .

BRAIN, 2009, 132 :3342-3352

[25] Selective stabilization of mammalian microRNAs by 3′ adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2 [J].

Katoh, Takayuki ;

Sakaguchi, Yuriko ;

Miyauchi, Kenjyo ;

Suzuki, Takeo ;

Kashiwabara, Shin-ichi ;

Baba, Tadashi ;

Suzuki, Tsutomu .

GENES & DEVELOPMENT, 2009, 23 (04) :433-438

[26] Multiple Sclerosis: MicroRNA Expression Profiles Accurately Differentiate Patients with Relapsing-Remitting Disease from Healthy Controls [J].

Keller, Andreas ;

Leidinger, Petra ;

Lange, Julia ;

Borries, Anne ;

Schroers, Hannah ;

Scheffler, Matthias ;

Lenhof, Hans-Peter ;

Ruprecht, Klemens ;

Meese, Eckart .

PLOS ONE, 2009, 4 (10)

[27] Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C-elegans [J].

Ketting, RF ;

Fischer, SEJ ;

Bernstein, E ;

Sijen, T ;

Hannon, GJ ;

Plasterk, RHA .

GENES & DEVELOPMENT, 2001, 15 (20) :2654-2659

[28] MicroRNA biogenesis: Coordinated cropping and dicing [J].

Kim, VN .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (05) :376-385

[29] miRBase: integrating microRNA annotation and deep-sequencing data [J].

Kozomara, Ana ;

Griffiths-Jones, Sam .

NUCLEIC ACIDS RESEARCH, 2011, 39 :D152-D157

[30] Combinatorial microRNA target predictions [J].

Krek, A ;

Grun, D ;

Poy, MN ;

Wolf, R ;

Rosenberg, L ;

Epstein, EJ ;

MacMenamin, P ;

da Piedade, I ;

Gunsalus, KC ;

Stoffel, M ;

Rajewsky, N .

NATURE GENETICS, 2005, 37 (05) :495-500

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