RNA-mediated gene activation

被引：61

作者：

Jiao, Alan L. ^{[1
]}

Slack, Frank J. ^{[1
]}

机构：

[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

来源：

EPIGENETICS | 2014年 / 9卷 / 01期

关键词：

transcriptional activation; saRNA; RNAa; non-coding RNA; eRNA; lincRNA; epigenetic; enhancer; LONG-NONCODING-RNA; EPIGENETIC MEMORY; TRANSCRIPTIONAL ACTIVATION; ANTISENSE TRANSCRIPTS; ARGONAUTE PROTEINS; NATURAL ANTISENSE; RESPONSE ELEMENTS; EXPRESSION; CHROMATIN; BIOGENESIS;

D O I：

10.4161/epi.26942

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regulation of gene expression by non-coding RNAs (ncRNAs) has become a new paradigm in biology. RNA-mediated gene silencing pathways have been studied extensively, revealing diverse epigenetic and posttranscriptional mechanisms. In contrast, the roles of ncRNAs in activating gene expression remains poorly understood. In this review, we summarize the current knowledge of gene activation by small RNAs, long non-coding RNAs, and enhancer-derived RNAs, with an emphasis on epigenetic mechanisms.

引用

页码：27 / 36

页数：10

共 89 条

[41] Argonaute2 is the catalytic engine of mammalian RNAi [J].

Liu, JD ;

Carmell, MA ;

Rivas, FV ;

Marsden, CG ;

Thomson, JM ;

Song, JJ ;

Hammond, SM ;

Joshua-Tor, L ;

Hannon, GJ .

SCIENCE, 2004, 305 (5689) :1437-1441

[42] MicroRNA-466l Upregulates IL-10 Expression in TLR-Triggered Macrophages by Antagonizing RNA-Binding Protein Tristetraprolin-Mediated IL-10 mRNA Degradation [J].

Ma, Feng ;

Liu, Xingguang ;

Li, Dong ;

Wang, Pin ;

Li, Nan ;

Lu, Liwei ;

Cao, Xuetao .

JOURNAL OF IMMUNOLOGY, 2010, 184 (11) :6053-6059

[43] MicroRNA-205-Directed Transcriptional Activation of Tumor Suppressor Genes in Prostate Cancer [J].

Majid, Shahana ;

Dar, Altaf A. ;

Saini, Sharanjot ;

Yamamura, Soichiro ;

Hirata, Hiroshi ;

Tanaka, Yuichiro ;

Deng, Guoren ;

Dahiya, Rajvir .

CANCER, 2010, 116 (24) :5637-5649

[44] Promoter RNA links transcriptional regulation of inflammatory pathway genes [J].

Matsui, Masayuki ;

Chu, Yongjun ;

Zhang, Huiying ;

Gagnon, Keith T. ;

Shaikh, Sarfraz ;

Kuchimanchi, Satya ;

Manoharan, Muthiah ;

Corey, David R. ;

Janowski, Bethany A. .

NUCLEIC ACIDS RESEARCH, 2013, 41 (22) :10086-10109

[45] Activation of LDL Receptor Expression by Small RNAs Complementary to a Noncoding Transcript that Overlaps the LDLR Promoter [J].

Matsui, Masayuki ;

Sakurai, Fuminori ;

Elbashir, Sayda ;

Foster, Donald J. ;

Manoharan, Muthiah ;

Corey, David R. .

CHEMISTRY & BIOLOGY, 2010, 17 (12) :1344-1355

[46] A global view of genomic information - moving beyond the gene and the master regulator [J].

Mattick, John S. ;

Taft, Ryan J. ;

Faulkner, Geoffrey J. .

TRENDS IN GENETICS, 2010, 26 (01) :21-28

[47] Argonaute proteins: functional insights and emerging roles [J].

Meister, Gunter .

NATURE REVIEWS GENETICS, 2013, 14 (07) :447-459

[48]

MELO C, 2013, CELL RES, V23, P1

[49] eRNAs Are Required for p53-Dependent Enhancer Activity and Gene Transcription [J].

Melo, Carlos A. ;

Drost, Jamo ;

Wijchers, Patrick J. ;

van de Werken, Harmen ;

de Wit, Elzo ;

Vrielink, Joachim A. F. Oude ;

Elkon, Ran ;

Melo, Sonia A. ;

Leveille, Nicolas ;

Kalluri, Raghu ;

de Laat, Wouter ;

Agami, Reuven .

MOLECULAR CELL, 2013, 49 (03) :524-535

[50] Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation [J].

Modarresi, Farzaneh ;

Faghihi, Mohammad Ali ;

Lopez-Toledano, Miguel A. ;

Fatemi, Roya Pedram ;

Magistri, Marco ;

Brothers, Shaun P. ;

van der Brug, Marcel P. ;

Wahlestedt, Claes .

NATURE BIOTECHNOLOGY, 2012, 30 (05) :453-+

← 1 2 3 4 5 6 7 8 9 →